97308-56-0

Usage

General Description

2-(2,2-diMethoxyethyl)nicotinaMide is a chemical compound with the molecular formula C12H19NO3. It is a derivative of nicotinamide and contains two methoxyethyl groups attached to the nitrogen atom. 2-(2,2-diMethoxyethyl)nicotinaMide has been investigated for its potential as a neuroprotective agent, and it has been shown to possess antioxidant and anti-inflammatory properties. Additionally, it has been studied for its potential use in the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease. 2-(2,2-diMethoxyethyl)nicotinaMide is also under investigation as a potential therapeutic agent for conditions such as stroke and traumatic brain injury. Its precise mechanisms of action and therapeutic potential are still being studied, but it shows promise as a potential treatment for neurodegenerative and neuroinflammatory conditions.

Upstream product

• 97308-49-1 2-trimethylsilylethynyl-3-pyridinecarbonitrile 
• 97308-52-6 2-(β,β-dimethoxyethyl)-3-pyridinecarbonitrile 

Downstream Products

• 23616-31-1 Naphthyridinon 
• 23616-32-2 5-chloro-[1,6]naphthyridine 
• 1351516-79-4 6-Amino-1,6-naphthyridin-5(6H)-iminium-2,4,6-trimethylbenzenesulfonate 
• 55570-60-0 1,6-naphthyridin-5-amine 
• 23616-31-1 1,6-naphthyridine-5(6H)-one 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Condensed Heteroaromatic Ring Systems. III. Synthesis of Naphthyridine Derivatives by Cyclization of Ethynylpyridinecarboxamides

Four kinds of naphthyridinones, i.e. 1,6-naphthyridin-5-one, 1,7-naphthyridin-8-one, 2,6-naphthyridin-2-one, and 2,7-naphthyridin-1-one derivatives, were commonly synthesized by the intramolecular cyclization of pyridinecarboxamides having an ethynyl group or β,β-dimethoxyethyl group adjacent to the carbamoyl group.The syntheses of the starting pyridine derivatives were easily accomplished by cross-coupling of the corresponding halopyridines with acetylenes.Keywords-intramolecular cyclization; palladium catalyst; trimethylsilylacetylene; naphthyridinone; pyridineacetaldehyde; 1(2H)-isoquinolone