97308-49-1

Usage

Uses

Used in Organic Synthesis:
2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE is used as a reagent in organic synthesis for its ability to participate in a range of chemical reactions, facilitating the formation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE is utilized in the development of new drug compounds, leveraging its unique structural features to create novel therapeutic agents.
Used in the Preparation of Functional Materials:
Due to its distinctive properties, 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE serves as a valuable building block for the preparation of various functional materials, contributing to advancements in material science and technology.

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 133816-00-9 phenyl(trimethylsilylethynyl)iodonium triflate 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 23616-31-1 Naphthyridinon 
• 138850-44-9 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide 
• 132898-85-2 2-<2-(N-(S)-1-benzylhydroxyethyl)amino>ethyl-nicotinonitrile 
• 132898-87-4 6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 132898-89-6 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-1,4,5,6,7,8-hexahydro-5-oxo-1,6-naphthyridine 
• 138921-62-7 2-<2-(N-(S)-1-benzylhydroxyethyl)amino>ethenylnicotinonitrile 
• 97308-56-0 2-(2,2-dimethoxy-ethyl)-nicotinamide 
• 23616-31-1 1,6-naphthyridine-5(6H)-one 
• 132898-81-8 2-Ethynylnicotinonitrile 
• 97308-52-6 2-(β,β-dimethoxyethyl)-3-pyridinecarbonitrile 
• 1351516-79-4 6-Amino-1,6-naphthyridin-5(6H)-iminium-2,4,6-trimethylbenzenesulfonate 
• 55570-60-0 1,6-naphthyridin-5-amine 
• 23616-32-2 5-chloro-[1,6]naphthyridine 
• 132898-86-3 6-((R)-1-Phenyl-ethyl)-7,8-dihydro-6H-[1,6]naphthyridin-5-one 

Relevant academic research and scientific papers

Arylation, Vinylation, and Alkynylation of Electron-Deficient (Hetero)arenes Using Iodonium Salts

Arylation, vinylation, and alkynylation of electron-deficient arenes and heteroarenes have been achieved by chemoselective C-H zincation followed by copper-catalyzed coupling reactions using iodonium salts. This approach offers a direct and general access to a wide scope of (hetero)biaryls as well as alkenylated and alkynylated heteroarenes under mild conditions. It is particularly useful and valuable for the rapid and modular synthesis of diverse (hetero)aryl compounds, as demonstrated in the synthesis of transient receptor potential vanilloid 1 (TRPV1) antagonists and angiotensin II receptor type 1 (AT1 receptor) antagonists.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Stereoselectivity of hydrogen transfer with chiral NADH models as a function of configuration and conformation

NADH model compounds bearing chiral amide groups have been synthesized. One of these models, 3, possessed the 1,6-naphtyridinone structure and the key step of its synthesis was a cross coupling reaction which was optimized on the basis of consideration of

Asymmetric Reductions with Freely and Non-freely Rotating Amide Group NADH Models

NADH models with a freely or a non freely rotating chiral amide group have been synthesized and used in the reduction of methyl benzoylformate.The same major enantiomer was obtained in all cases.A blocked reagent bearing a phenylalaninol group as chiral auxiliary allows one to obtain a high e.e.

Condensed Heteroaromatic Ring Systems. III. Synthesis of Naphthyridine Derivatives by Cyclization of Ethynylpyridinecarboxamides

Four kinds of naphthyridinones, i.e. 1,6-naphthyridin-5-one, 1,7-naphthyridin-8-one, 2,6-naphthyridin-2-one, and 2,7-naphthyridin-1-one derivatives, were commonly synthesized by the intramolecular cyclization of pyridinecarboxamides having an ethynyl group or β,β-dimethoxyethyl group adjacent to the carbamoyl group.The syntheses of the starting pyridine derivatives were easily accomplished by cross-coupling of the corresponding halopyridines with acetylenes.Keywords-intramolecular cyclization; palladium catalyst; trimethylsilylacetylene; naphthyridinone; pyridineacetaldehyde; 1(2H)-isoquinolone