97480-49-4

Usage

Uses

Used in Pharmaceutical Industry:
(CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical sector, (CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER is utilized as a precursor in the production of agrochemicals. Its role in the synthesis process helps create effective solutions for agricultural applications, such as pesticides and herbicides, to protect crops and enhance yield.

InChI:InChI=1/C6H10ClF2O4P/c1-3-12-14(11,13-4-2)6(8,9)5(7)10/h3-4H2,1-2H3

Upstream product

• 75-44-5 phosgene 
• 82845-20-3 [(diethoxyphosphoryl)difluoromethyl]zinc bromide 
• 97480-37-0 Diethyl phosphoryl-2,2-difluoroacetic acid 

Downstream Products

• 1217898-93-5 diethyl 2-(2,4-difluorophenylamino)-1,1-difluoro-2-oxoethylphosphonate 
• 1217898-98-0 C₂₅H₃₂F₄N₂O₈P₂ 
• 1217898-88-8 diethyl 2-(benzylamino)-1,1-difluoro-2-oxoethylphosphonate 

Relevant academic research and scientific papers

The amination of difluoro(diethoxyphosphoryl)acetyl chloride: Facile synthetic route to novel amides containing difluoromethylenephosphonate moiety

A convenient route for the synthesis of novel amides containing at least one β-keto-α,α-difluoromethylenephosphonate group has been elaborated. The procedure requires simple stirring of an amine and difluoro(diethoxyphosphoryl)acetyl chloride in THF in th

Preparation of Difluorophosphonoacetic Acid and Its Derivatives

The preparation of ethyl difluoro(diethoxyphosphinyl)acetate (1) has been effected by the acylation of zinc bromide with ethyl chloroformate in the presence of a catalytic amount of cuprous bromide.Similarly prepared were ethyl difluoro(diethoxyphosphinyl)pyruvate (2) and N,N-diethyldifluoro(diethoxyphosphinyl)acetamide (3).Bromotrimethylsilane selectively reacted with 1 to yield ethyl difluoroacetate (9).The remaining ethyl carboxylic ester of 9 reacted with iodotrimethylsilane to produce trimethylsilyl difluoroacetate (10), which was subsequently hydrolyzed to yield difluorophosphonoacetic acid (8).The phosphonate 9 was gently chlorinated to yield ethyl difluoro(dichlorophosphinyl)acetate (11).