97551-19-4Relevant articles and documents
Synthesis of Chiral Alkenyl Cyclopropane Amino Acids for Incorporation into Stapled Peptides
Yuen, Tsz Ying,Brown, Christopher J.,Tan, Yaw Sing,Johannes, Charles W.
, p. 1556 - 1566 (2020)
α,α′-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α′-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthes
BUILDING BLOCKS FOR STAPLED PEPTIDES
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Paragraph 00097; 00099, (2018/10/19)
This invention relates to a method for producing an alkenyl 1 -aminocyclopropane-1 -carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B is R an
Metallophosphites as Umpolung Catalysts: The Enantioselective Cross Silyl Benzoin Reaction
Linghu, Xin,Potnick, Justin R.,Johnson, Jeffrey S.
, p. 3070 - 3071 (2007/10/03)
Carbonyl polarity reversal (umpolung) has been realized employing metallophosphites as catalysts. As a result, nonenzymatic asymmetric cross silyl benzoin reactions have been achieved, giving optically active silyl ether-protected benzoin adducts. The reaction is general with respect to aryl, alkyl, and heterocyclic substrates with good to excellent yields and good to excellent enantioselectivities. Copyright
