97551-19-4

Basic information

• Product Name: (R)-2-hydroxy-3-methyl-1-phenylbutan-1-one
• Synonyms: (R)-2-hydroxy-3-methyl-1-phenylbutan-1-one
• CAS NO: 97551-19-4
• Molecular Weight: 178.231
• Mol File: 97551-19-4.mol

Chemical Properties

• CAS DataBase Reference: (R)-2-hydroxy-3-methyl-1-phenylbutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-hydroxy-3-methyl-1-phenylbutan-1-one(97551-19-4)
• EPA Substance Registry System: (R)-2-hydroxy-3-methyl-1-phenylbutan-1-one(97551-19-4)

Safety Data

• Hazardous Substances Data: 97551-19-4(Hazardous Substances Data)

Upstream product

• 104426-40-6 3-methyl-1-oxo-1-phenylbutan-2-yl acetate 
• 63935-93-3 benzoyltriethylsilane 
• 67-63-0 isopropyl alcohol 
• 17407-56-6 (R)-2-Hydroxy-3-methylbutyric acid 
• 100-58-3 phenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 78-84-2 isobutyraldehyde 

Relevant articles and documents

Synthesis of Chiral Alkenyl Cyclopropane Amino Acids for Incorporation into Stapled Peptides

α,α′-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α′-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthes

Rearrangement of N- tert-Butanesulfinyl Enamines for Synthesis of Enantioenriched α-Hydroxy Ketone Derivatives

Treating chiral N-tert-butanesulfinyl ketimines with potassium hexamethyldisilazide (or potassium tert-butoxide) and methyl triflate gives N-methylated N-tert-butanesulfinyl enamine intermediates that undergo stereoselective [2,3]-rearrangement to afford α-sulfenyloxy ketones with excellent enantiopurities. This cascade of enamination-N-methylation-rearrangement was even used to generate acyclic tertiary α-hydroxy ketones bearing two α-substituents showing negligible differences in bulkiness, such as methyl and ethyl groups.

BUILDING BLOCKS FOR STAPLED PEPTIDES

This invention relates to a method for producing an alkenyl 1 -aminocyclopropane-1 -carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B is R an

Benzaldehyde lyase-catalyzed diastereoselective C-C bond formation by simultaneous carboligation and kinetic resolution

Enzymes create chiral microenvironments that may simultaneously generate several stereogenic centers in the same catalytic cycle, broadening the possibilities of biocatalysis. Benzaldehyde lyase (BAL) affords highly diastereoselective α-hydroxy-ketones by simultaneously performing ligation and kinetic resolution of a racemic aldehyde. Thus, to the well-known enantioselective BAL-carboligation of aldehydes (C-C bond formation), another property, namely diastereoselectivity, is added in this paper for the first time.

Metallophosphites as Umpolung Catalysts: The Enantioselective Cross Silyl Benzoin Reaction

Carbonyl polarity reversal (umpolung) has been realized employing metallophosphites as catalysts. As a result, nonenzymatic asymmetric cross silyl benzoin reactions have been achieved, giving optically active silyl ether-protected benzoin adducts. The reaction is general with respect to aryl, alkyl, and heterocyclic substrates with good to excellent yields and good to excellent enantioselectivities. Copyright

Preparation of Optically Active α-Acetoxyacylophenones via Enzyme Mediated Hydrolysis

Microorganisms that hydrolyzes α-acetoxyacylophenones were screened, and it was found that Pichia miso IAM 4682, a type culture belonging to yeast, gave the best results.The esterase of this microbe hydrolyzed (R)-acetates in a highly enantioselective manner.