97585-03-0Relevant academic research and scientific papers
Palladium-Catalyzed α,β-Dehydrogenation of Esters and Nitriles
Chen, Yifeng,Romaire, Justin P.,Newhouse, Timothy R.
, p. 5875 - 5878 (2015)
A highly practical and general palladium-catalyzed methodology for the α,β-dehydrogenation of esters and nitriles is reported. Generation of a zinc enolate or (cyanoalkyl)zinc species followed by the addition of an allyl oxidant and a palladium catalyst results in synthetically useful yields of α,β-unsaturated esters, lactones, and nitriles. Preliminary mechanistic investigations are consistent with reversible β-hydride elimination and turnover-limiting, propene-forming reductive elimination.
