97693-25-9

Upstream product

• 97693-21-5 2-methylsulfanyl-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 70638-52-7 5-cyano-6-phenyl-2-thiouracil 
• 100-52-7 benzaldehyde 

Downstream Products

• 97693-30-6 2-{N'-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-hydrazino}-6-oxo-4-phenyl-1,6-dihydro-pyrimidine-5-carbonitrile 
• 118521-19-0 2-(4-Chloro-3,5-dimethyl-pyrazol-1-yl)-6-oxo-4-phenyl-1,6-dihydro-pyrimidine-5-carbonitrile 
• 118521-18-9 5-cyano-2(3,5-dimethyl)-1-pyrazolyl-6-phenyl pyrimidin-4(3H) one 
• 126278-14-6 6-cyano-7-phenyl <1,2,4>triazolo<4,3-a>pyrimidin-5(8H) one 
• 126278-13-5 5-Cyano-2-(N-formylhydrazino)-6-phenyl-3,4-dihydropyrimidin-4-one 
• 97693-30-6 2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-6-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile 
• 126278-05-5 6-Cyano-3,7-diphenyl-1,2,4-triazolo<4,3-a>pyrimidin-5(8H)-one 
• 126278-04-4 2-{[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-6-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile 
• 126278-03-3 2-{[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-6-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile 
• 97693-29-3 4-Oxo-6-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-hydrazono}-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile 
• 126278-01-1 2-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-6-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile 
• 126278-11-3 5-cyano-2-(N-acetyl hydrazono)-6-phenyl-1,2,3,4-tetrahydro pyrimidin-4-one 

Relevant academic research and scientific papers

Synthesis and Anti-HBV Activity of Novel Substituted Pyrimidine Glycosides and Their Acyclic Analogues

New aryl substituted uracil and thiouracil glycosides are synthesized by glycosylation at N1 in the pyrimidine nucleus using glycopyranosyl halides in basic medium. In addition C-linked hydrazinyl acyclic sugar derivatives exhibiting different

Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma

New anticancer agents are highly needed to overcome cancer cell resistance. A novel series of pyrimidine pyrazoline-anthracene derivatives (PPADs) (4a-t) were designed and synthesised. The anti-liver cancer activity of all compounds was screened in vitro against two hepatocellular carcinoma (HCC) cell lines (HepG2 and Huh-7) as well as normal fibroblast cells by resazurin assay. The designed compounds 4a-t showed a broad-spectrum anticancer activity against the two cell lines and their activity was more prominent on cancer compared to normal cells. Compound 4e showed high potency against HepG2 and Huh-7 cell lines ((IC50=5.34 and 6.13 μg/mL, respectively) comparable to that of doxorubicin (DOX) activities. A structure activity relationship (SAR) has been investigated and compounds 4e, 4i, 4m, and 4q were the most promising anticancer agents against tested cell lines. These compounds induced apoptosis in HepG2 and Huh-7 cells through significant activation of caspase 3/7 at all tested concentrations. In conclusion, 4e could be a potent anticancer drug.

NEW PYRIDINE DERIVATIVES: SYNTHESIS AND APPLICATION OF THIAZOLO-TRIAZOLO-PYRIMIDINE AS BACTERICIDES, FUNGICIDES AND BIOREGULATORS

5-Cyano-4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (IIa-g); and with chloroacetic acid ethyl chloroacetate to give compounds III and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g).The parent thiazolopyrimidine (VI) was prepared from compound III by refluxing with acetic anhydride.Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo pyrimidine derivatives.The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure.Key words: Pyrimidinethione; thiazolopyrimidine; triazolopyrimidine; synthesis and reactions; biological activity.

A One-Step Synthesis of 2-Methylthio-6-oxopyrimidine Derivatives: Preparation of Fused Pyrimidinones

Condensation of a ternary mixture of ethyl cyanoacetate, S-methylisothiourea and aromatic aldehydes in pyridine afforded directly the 4-aryl-5-cyano-6-oxopyrimidines IV in good yields.Alkylation of IV with alkyl halides in alkaline medium yielded the 1-al