97693-30-6Relevant academic research and scientific papers
NEW PYRIDINE DERIVATIVES: SYNTHESIS AND APPLICATION OF THIAZOLO-TRIAZOLO-PYRIMIDINE AS BACTERICIDES, FUNGICIDES AND BIOREGULATORS
Khalil, Zarif Hallem,Hafez, Ali Ahmed Abdel,Ahmed, Ahmed Abdo
, p. 81 - 94 (2007/10/02)
5-Cyano-4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (IIa-g); and with chloroacetic acid ethyl chloroacetate to give compounds III and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g).The parent thiazolopyrimidine (VI) was prepared from compound III by refluxing with acetic anhydride.Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo pyrimidine derivatives.The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure.Key words: Pyrimidinethione; thiazolopyrimidine; triazolopyrimidine; synthesis and reactions; biological activity.
A One-Step Synthesis of 2-Methylthio-6-oxopyrimidine Derivatives: Preparation of Fused Pyrimidinones
Hussain, S. M.,El-Barbary, A. A.,Mansour, S. A.
, p. 169 - 171 (2007/10/02)
Condensation of a ternary mixture of ethyl cyanoacetate, S-methylisothiourea and aromatic aldehydes in pyridine afforded directly the 4-aryl-5-cyano-6-oxopyrimidines IV in good yields.Alkylation of IV with alkyl halides in alkaline medium yielded the 1-al
