97906-32-6

Upstream product

• 74-85-1 ethene 
• 78-84-2 isobutyraldehyde 
• 187324-70-5 (1'R)-phenyl-(2'S)-[(phenylmethyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]-propyl (3R)-hydroxy-(2R),4-dimethylpentanoate 

Downstream Products

• 1380244-59-6 (2R,4S)-4-((4S,5S,6S)-6-isopropyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-3-oxopentan-2-yl benzoate 
• 1380244-49-4 (2R,4S,5S,6R,7S)-5-hydroxy-7-(4-methoxybenzyloxy)-4,6,8-trimethyl-3-oxononan-2-yl benzoate 
• 1380244-48-3 (2R,3S)-3-(4-methoxybenzyloxy)-2,4-dimethylpentan-1-ol 
• 474333-63-6 (2R,4S,5R)-4-isopropyl-2-(4-methoxyphenyl)-5-methyl-1,3-dioxane 
• 114066-23-8 [(2R,4S,6R,8R,9S)-2-((E)-4-Bromo-3-methyl-but-2-enyl)-8-isopropyl-9-methyl-1,7-dioxa-spiro[5.5]undec-4-yloxy]-tert-butyl-diphenyl-silane 
• 116315-42-5 (2S,4S,10R)-1,4-dibenzyloxy-10-(dimethyl-t-butylsiloxy)-2-hydroxy-9,11-dimethyldodec-7-yn-6-one 
• 97848-45-8 (2R,3R,4S,5S,6R,8S,10S)-10-benzyloxy-8-benzyloxymethyl-5-chloro-2-isopropyl-3-methyl-1,7-dioxaspiro<5.5>undecan-4-ol 
• 97848-45-8 (2R,3R,4R,5R,6R,8S,10S)-10-benzyloxy-8-benzyloxymethyl-5-chloro-2-isopropyl-3-methyl-1,7-dioxaspiro<5.5>undec-4-ol 
• 97848-40-3 (4S,6S)-4-Benzyloxy-6-benzyloxymethyl-2-[(3S,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-hex-1-ynyl]-tetrahydro-pyran-2-ol 
• 97848-43-6 (4S,6S)-4-benzyloxy-6-benzyloxymethyl-2-<(3S,4R,Z)-4-hydroxy-3,5-dimethylhex-1-enyl>-2-methoxytetrahydropyran 
• 97848-42-5 (4S,6S)-4-benzyloxy-6-benzyloxymethyl-2-<(3S,4R)-4-hydroxy-3,5-dimethylhex-1-ynyl>-2-methoxytetrahydropyran 
• 97848-44-7 (2R,3S,6R,8S,10S)-10-benzyloxy-8-benzyloxymethyl-2-isopropyl-3-methyl-1,7-dioxaspiro<5.5>undec-4-ene 
• 116315-35-6 (2S,3R)-3-dimethyl-t-butylsiloxy-2,4-dimethylpentyl benzoate 
• 179815-61-3 C₅₈H₈₀O₆SSi₂ 

Relevant academic research and scientific papers

Domino hydroformylation/enantioselective cross-aldol addition

A domino hydroformylation/enantioselective cross-aldol reaction sequence is reported. Starting from simple alkenes enantiomerically pure aldol addition products, which represent valuable building blocks for polypropionate construction, can be obtained in a one-pot operation.

Boron-mediated aldol reaction of carboxylic esters: Complementary anti- and syn-selective asymmetric aldol reactions

The boron-mediated aldol reaction of carboxylic esters is described in detail. Contrary to the general belief that carboxylic esters are inert under the condition of the boron enolate formation, propionate esters are enolized with certain combinations of a boron triflate and an amine. More importantly, the stereochemical course of the aldol reaction can be controlled by the judicious selection of the enolization reagents. Treatment of propionate esters with c-Hex2BOTf and triethylamine produces anti-aldol products, and that with Bu2BOTf and diisopropylethylamine gives syn-aldol products selectively after reaction with aldehydes. Complementary anti- and syn-selective asymmetric aldol reactions with structurally related, readily available chiral norephedrine-derived propionate esters are developed.