97927-59-8

Upstream product

• 75-44-5 phosgene 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 226250-01-7 2-(tert-butoxycarbonylamino)-4,5-difluorobenzoic acid 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1261594-28-8 3-benzyl-7,8-difluoro-1-methyl-3,4-dihydro-1H-benzo[d][1,3]diazepine-5(2H)-one 
• 761403-98-9 1-benzyl-3-tert-butoxy-6-fluoro-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione 
• 761403-89-8 1-benzyl-3-tert-butoxy-6,7-difluoro-1H-quinazoline-2,4-dione 
• 761403-79-6 2-amino-N-tert-butoxy-4,5-difluoro-benzamide 
• 1361967-31-8 6,7-difluoro-3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4(1H)-one 

Relevant academic research and scientific papers

A phosgene and peroxide-free one-pot tandem synthesis of isatoic anhydrides involving anthranilic acid, boc anhydride and 2-chloro-N-methyl pyridinium iodide

A phosgene and peroxide-free approach for the synthesis of isatoic anhydrides has been described. The synthesis involves the carbamate formation with boc anhydride followed by in situ cyclization to afford the isatoic anhydride. The importance of this synthetic strategy is in the ease of operation, scalability and preparation from readily available raw materials.

PROLYL HYDROXYLASE ANTAGONISTS

This invention relates to certain 2-[(quinolin-3-yl)carbonyl]aminoacetic acid derivatives of formula (I), where the various groups are defined herein, and which are useful in treating anemia.

Synthesis and structural-activity relationships of 3-hydroxyquinazoline-2, 4-dione antibacterial agents

The synthesis and SAR of the 3-hydroxyquinazoline diones, a novel class of bacterial topoisomerase inhibitors, is reported. A series of 3-hydroxyquinazoline-2,4-diones was synthesized and evaluated for antibacterial activity. This series represents a novel addition to the DNA gyrase inhibitor class of antibacterials. Appropriate substitutions onto the core template yielded compounds with excellent potency against E. coli gyrase and significant in vitro Gram-negative and Gram-positive antibacterial activity.

Antihypertensive 3-tetrazoyl-4-quinolones

Novel quinolones of formula I STR1 and pharmaceutically acceptable acid addition salts thereof in which the dotted line between positions 2 and 3 of the quinolone ring represents an optional bond, R is hydrogen, 1-methyl or 2-lower alkyl; R1 is lower alkyl; R2 is hydrogen, halo, lower alkyl, lower alkoxy, trifluoromethyl, cyano, difluoromethoxy, methylsulphinyl, phenylsulphinyl or the group --NR4 R5 or the N-oxide thereof wherein R4 and R5, which may be the same or different, are lower alkyl or, together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino radical; and R3 is hydrogen, fluoro, lower alkyl or lower alkoxy provided that, when R3 is lower alkoxy, R2 is other than lower alkoxy have utility as antihypertensive agents. Processes for preparing the quinolones and pharmaceutical compositions containing them are disclosed.