98006-91-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-Methylpyrazine-2-carbonitrile is utilized as a key raw material in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical properties make it an essential component in the development of new drugs and agricultural products.
Used as a Flavoring Agent in Food and Beverages:
Leveraging its pleasant, nutty aroma, 5-Methylpyrazine-2-carbonitrile is employed as a flavoring agent in the food and beverage industry. It enhances the taste and aroma profile of a wide range of products, contributing to their overall sensory appeal.
Used as a Precursor in Organic Compounds Synthesis:
Recognized for its potential as a precursor, 5-Methylpyrazine-2-carbonitrile plays a crucial role in the formation of various organic compounds. It serves as a valuable building block in the chemical industry, enabling the creation of a diverse array of chemical products.

InChI:InChI=1/C6H5N3/c1-5-3-9-6(2-7)4-8-5/h3-4H,1H3

Upstream product

• 25594-37-0 2-methylpyrazine 4-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 88394-05-2 3-carboxamido-2-hydroxy-6-methylpyrazine 
• 181284-14-0 3-chloro-5-methylpyrazine-2-carbonitrile 

Downstream Products

• 132664-85-8 (5-methylpyrazine-2-yl)methylamine 
• 22047-27-4 1-(5-methylpyrazin-2-yl)ethanone 
• 5521-57-3 5‐methylpyrazine-2-carboxamide 

Relevant academic research and scientific papers

Preparation method, product and application of 2-amino-5-methylpyrazine

The invention belongs to the field of chemical synthesis, and relates to a preparation method, product and application of 2-amino-5-methylpyrazine. The preparation method comprises the following steps: reacting 2-aminomalonamide with pyruvic aldehyde to generate 2-methyl-5-hydroxy-4-pyrazinamide; enabling 2-methyl-5-hydroxy-4-pyrazinamide to react with phosphorus oxychloride so as to generate 2-methyl-5-chloro-4-cyanopyrazine; carrying out a hydrogenation reaction on the 2-methyl-5-chloro-4-cyanopyrazine to generate 2-methyl-4-cyanopyrazine, and hydrolyzing the 2-methyl-4-cyanopyrazine to obtain 2-methyl-4-amide pyrazine; and carrying out Hofmann degradation on the 2-methyl-4-amide pyrazine so as to obtain the 2-methyl-5-aminopyrazine. The method belongs to a brand-new 2-amino-5-methylpyrazine preparation method, is simple and convenient to operate, high in yield and low in cost, and is suitable for industrial large-scale production.

Studies on Pyrazines. Part 22. Lewis Acid-Mediated Cyanation of Pyrazine N-Oxides with Trimethylsilyl Cyanide: New Route to 2-Substituted 3-Cyanopyrazines

Reaction of 3-substituted pyrazine 1-oxides with trimethylsilyl cyanide in the presence of triethylamine in acetonitrile gave the corresponding cyanopyrazines, yields of which depended remarkably on the substituent.Electron-donating groups enhanced the cyanation with high regioselectivity to 2-substituted 3-cyanopyrazines, while a chloro substituent suppressed the conversion.Addition of zinc halide to the reaction mixture, in most cases, increased the reactivity and improved the regioselectivity.On the other hand, the N-oxides carrying an electron-withdrawing methoxycarbonyl or N-butylcarbamoyl group underwent the cyanation, without need for the Lewis acid, to provide a mixture of nearly equal amounts of 2-substituted 3- and 5-cyanopyrazines.The latter compound was exclusively obtained when 3-methoxycarbonyl- or 3-cyanopyrazine 1-oxide was treated with diethoxyphosphoryl cyanide.