88394-05-2

Basic information

• Product Name: Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI)
• Synonyms: Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI);PyrazinecarboxaMide, 3,4-dihydro-5-Methyl-3-oxo-;3,4-Dihydro-5-methyl-3-oxo-2-pyrazinecarboxamide;3-Hydroxy-5-methyl-pyrazinecarboxamide;NSC 157781;6-methyl-2-oxo-1H-pyrazine-3-carboxamide;Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo-（WS204366）
• CAS NO: 88394-05-2
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.13868
• Product Categories: AMIDE
• Mol File: 88394-05-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 219-220℃
• Boiling Point: 528°C at 760 mmHg
• Flash Point: 273.1°C
• Appearance: /
• Density: 1.52
• Vapor Pressure: 9.15E-12mmHg at 25°C
• Refractive Index: 1.662
• PKA: 10.75±0.60(Predicted)
• CAS DataBase Reference: Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI)(88394-05-2)
• EPA Substance Registry System: Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI)(88394-05-2)

Safety Data

• Hazardous Substances Data: 88394-05-2(Hazardous Substances Data)

Usage

General Description

Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI) is a chemical compound with the molecular formula C6H8N2O2. It is a derivative of pyrazinecarboxamide, and is also known as 3,4-dihydro-5-methyl-3-oxo-pyrazine-2-carboxamide. Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI) has potential industrial and pharmaceutical applications, particularly in the field of organic synthesis. It may also have biological activities and pharmaceutical properties that make it useful in the development of new drugs. The specific uses and properties of this chemical would need further study and investigation.

InChI:InChI=1/C6H7N3O2/c1-3-2-8-4(5(7)10)6(11)9-3/h2H,1H3,(H2,7,10)(H,9,11)

Upstream product

• 62009-47-6 2-aminopropanediamide 
• 78-98-8 2-oxopropanal 

Downstream Products

• 98006-91-8 5-methylpyrazine-2-carbonitrile 
• 5521-58-4 5-methylpyrazin-2-amine 
• 5521-57-3 5‐methylpyrazine-2-carboxamide 
• 120992-57-6 2-Hydroxy-6-methylpyrazine-3-carboxylic acid 
• 5521-55-1 2-methylpyrazin-5-carboxylic acid 
• 120992-57-6 5-methyl-3-oxo-3,4-dihydro-pyrazine-2-carboxylic acid 
• 43029-20-5 3-amino-6-methyl-2(1H)-pyrazinone 

Relevant articles and documents

Preparation method, product and application of 2-amino-5-methylpyrazine

The invention belongs to the field of chemical synthesis, and relates to a preparation method, product and application of 2-amino-5-methylpyrazine. The preparation method comprises the following steps: reacting 2-aminomalonamide with pyruvic aldehyde to generate 2-methyl-5-hydroxy-4-pyrazinamide; enabling 2-methyl-5-hydroxy-4-pyrazinamide to react with phosphorus oxychloride so as to generate 2-methyl-5-chloro-4-cyanopyrazine; carrying out a hydrogenation reaction on the 2-methyl-5-chloro-4-cyanopyrazine to generate 2-methyl-4-cyanopyrazine, and hydrolyzing the 2-methyl-4-cyanopyrazine to obtain 2-methyl-4-amide pyrazine; and carrying out Hofmann degradation on the 2-methyl-4-amide pyrazine so as to obtain the 2-methyl-5-aminopyrazine. The method belongs to a brand-new 2-amino-5-methylpyrazine preparation method, is simple and convenient to operate, high in yield and low in cost, and is suitable for industrial large-scale production.

BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.