5521-57-3

Basic information

• Product Name: 5-METHYL-PYRAZINE-2-CARBOXAMIDE
• Synonyms: 5-METHYL PYRAZINAMIDE;5-METHYL-PYRAZINE-2-CARBOXAMIDE;Pyrazinecarboxamide, 5-methyl- (7CI,8CI,9CI);5-Methyl-2-pyrazinecarboxamide;5-Methyl-pyrazine-2-carboxylic acid amide;2-Pyrazinecarboxamide, 5-methyl-
• CAS NO: 5521-57-3
• Molecular Formula: C₆H₇N₃O
• Molecular Weight: 137.14
• Product Categories: AMIDE
• Mol File: 5521-57-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 212°C
• Boiling Point: 307.7 °C at 760 mmHg
• Flash Point: 139.9 °C
• Appearance: /
• Density: 1.237 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.12±0.50(Predicted)
• CAS DataBase Reference: 5-METHYL-PYRAZINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-PYRAZINE-2-CARBOXAMIDE(5521-57-3)
• EPA Substance Registry System: 5-METHYL-PYRAZINE-2-CARBOXAMIDE(5521-57-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5521-57-3(Hazardous Substances Data)

Usage

General Description

5-Methyl-pyrazine-2-carboxamide is a chemical compound with the molecular formula C6H7N3O. It is a pyrazine derivative and is commonly used as a flavoring agent in the food industry. It has a slightly sweet and nutty odor and is often used in the production of various food and beverage products to enhance their overall flavor profile. Additionally, it is also used in the pharmaceutical industry as a building block for the synthesis of various drugs and drug intermediates. The compound is considered to be relatively safe for consumption and is approved by regulatory agencies for use in food products.

Upstream product

• 98006-91-8 5-methylpyrazine-2-carbonitrile 
• 181284-14-0 3-chloro-5-methylpyrazine-2-carbonitrile 
• 88394-05-2 3-carboxamido-2-hydroxy-6-methylpyrazine 
• 41110-33-2 5-methylpyrazine-2-carboxylic acid methyl ester 
• 5521-55-1 2-methylpyrazin-5-carboxylic acid 
• 123-32-0 2,5-dimethyl-pyrazine 

Downstream Products

• 5521-58-4 5-methylpyrazin-2-amine 
• 98006-90-7 2-bromo-5-methyl-pyrazine 
• 51037-30-0 acipimox 

Relevant articles and documents

Preparation method, product and application of 2-amino-5-methylpyrazine

The invention belongs to the field of chemical synthesis, and relates to a preparation method, product and application of 2-amino-5-methylpyrazine. The preparation method comprises the following steps: reacting 2-aminomalonamide with pyruvic aldehyde to generate 2-methyl-5-hydroxy-4-pyrazinamide; enabling 2-methyl-5-hydroxy-4-pyrazinamide to react with phosphorus oxychloride so as to generate 2-methyl-5-chloro-4-cyanopyrazine; carrying out a hydrogenation reaction on the 2-methyl-5-chloro-4-cyanopyrazine to generate 2-methyl-4-cyanopyrazine, and hydrolyzing the 2-methyl-4-cyanopyrazine to obtain 2-methyl-4-amide pyrazine; and carrying out Hofmann degradation on the 2-methyl-4-amide pyrazine so as to obtain the 2-methyl-5-aminopyrazine. The method belongs to a brand-new 2-amino-5-methylpyrazine preparation method, is simple and convenient to operate, high in yield and low in cost, and is suitable for industrial large-scale production.

Catalytic synthesis of pyrazinamide from 2,5-dimethylpyrazine

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