98114-50-2Relevant academic research and scientific papers
An efficient method for the synthesis of a novel leukotriene B4 receptor antagonist, ONO-4057, via Michael reaction of dihydroresorcinol
Konno, Mitoshi,Nakae, Takahiko,Sakuyama, Shigeru,Imaki, Katsuhiro,Nakai, Hisao,Hamanaka, Nobuyuki
, p. 1472 - 1474 (2007/10/03)
A practical method for the synthesis of ONO-4057, a highly potent and orally active leukotriene B4 (LTB4) receptor antagonist, was developed. This method includes improved synthesis of a key intermediate, 1,3-dioxo-2-(2-ethoxycarbony lethyl)cyclohexane (6).
