98289-62-4Relevant academic research and scientific papers
HBr/H2O2-mediated formation of C–S bond with thiosulfates
Zhang, Rongxing,Jin, Shengzhou,Wan, Yuanxing,Lin, Sen,Yan, Zhaohua
, p. 841 - 847 (2018/02/06)
A novel, efficient, and green protocol to construct C–S bond has been developed via HBr/H2O2-mediated sulfenylation of styrenes and 4-hydroxycoumarins leading to unsymmetrical sulfides. Various unsymmetrical sulfides were prepared in one step with moderate to good yields using environmentally-friendly H2O2 as oxidant and HBr as catalyst. Based on the preliminary experimental results, a plausible reaction mechanism was proposed for HBr/H2O2-mediated formation of C–S bond with thiosulfates.
A N - substituted amide derivative and its preparation method
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Paragraph 0162; 0163, (2017/08/25)
The invention provides an N-substituted amide derivative and a preparation method thereof. An adopted catalyst system has very high chemical selectivity, so that no side reaction occurs in the reaction process, the utilization rate of raw materials is greatly increased, and the yield of a final product is increased. One-step reaction is adopted, reaction steps are reduced, waste caused by failure of 100% utilization of raw materials and intermediate products in the multi-step reaction process is reduced, and the yield of the final product is increased to a certain extent. Compared with the prior art, the preparation method has the advantages that the yield is greatly increased, and the average yield is 90%; besides, the catalyst system used in the process is a non-heavy-metal catalyst system and has advantages that toxicity and residues are avoided and the substrate range is wide, so that the operation process is healthy and environment-friendly, and the selective range is wide.
NaI-Mediated Acetamidosulfenylation of Alkenes with Bunte Salts as Thiolating Reagent Leading to β-Acetamido Sulfides
Zhang, Rongxing,Yan, Zhaohua,Wang, Dingyi,Wang, Yuanxing,Lin, Sen
supporting information, p. 1195 - 1200 (2017/06/13)
A direct and efficient method for the acetamidosulfenylation reaction of alkenes was developed, in which NaI was used as a catalyst, DMSO as the oxidant, nitriles as both the solvent and nucleophiles and stable, readily available Bunte salts as thiolating reagents. The reactions were carried out under mild conditions generating β-acetamido sulfides in good yields. Moreover, the reaction can be performed when alcohols are used as nucleophiles providing the corresponding β-alkoxysulfides in moderate yields, respectively.
Molecular Iodine-Mediated Difunctionalization of Alkenes with Nitriles and Thiols Leading to β-Acetamido Sulfides
Cui, Huanhuan,Liu, Xiaoxia,Wei, Wei,Yang, Daoshan,He, Chenglong,Zhang, Tiantian,Wang, Hua
, p. 2252 - 2260 (2016/04/01)
A direct difunctionalization protocol of alkenes with nitriles and thiols toward β-acetamido sulfide derivatives has been proposed under metal-free synthesis conditions. The present protocol provides the facile and highly efficient synthesis of various β-acetamido sulfides in a scaled-up manner with good to excellent yields simply using inexpensive molecular iodine as a catalyst, DMSO as a mild oxidant, and readily available thiols as thiolating reagents.
NaI-Mediated Acetamidosulphenylation of Alkenes with Nitriles as the Nucleophiles: A Direct Access to Acetamidosulfides
Zheng, Yang,He, Yue,Rong, Guangwei,Zhang, Xiaolu,Weng, Yuecheng,Dong, Kuiyong,Xu, Xinfang,Mao, Jincheng
supporting information, p. 5444 - 5447 (2015/11/18)
An example of a transition-metal-free, direct, and efficient acetamidosulphenylation reaction of alkenes using nitriles as the nucleophiles via a radical process is presented. This reaction shows a broad substrate scope and high regioselectivity and provides straightforward access to acetamidosulfide derivatives in moderate to high yields.
Additions to Alkenes via Metal Ion-Promoted Oxidation of Dialkyl and Diaryl Disulphides
Bewick, Alan,Mellor, John M.,Owton, W. Martin
, p. 1039 - 1044 (2007/10/02)
Reactions of alkenes with di-n-propyl, diphenyl, and dibenzyl disulphide in the presence of lead(IV) salts in trifluoroacetic acid-dichloromethane are described.The products, vicinal trifluoroacetoxysulphides, are obtained in higher yields with manganese(III) salts as the oxidant.Alternative reaction conditions with use of iron(III) salts or in the absence of added metal salts are also described.Trifluoroacetoxysulphides derived from diphenyl disulphide react with acetonitrile under Ritter conditions to give acetamidosulphides but trifluoroacetoxysulphides derived from dibenzyl disulphide only give the vicinal acetamidosulphides in poor yield as a result of an alternative reaction pathway affording benzylacetamide.Conversions of acetamidosulphides into aminosulphides and into acetamidothiols are described.
