98303-49-2

Basic information

• Product Name: trans,trans-bis(4-(dimethylamino)benzylidene)acetone
• Synonyms: trans,trans-bis(4-(dimethylamino)benzylidene)acetone
• CAS NO: 98303-49-2
• Molecular Formula: C₂₁H₂₄N₂O
• Molecular Weight: 0
• Mol File: 98303-49-2.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: trans,trans-bis(4-(dimethylamino)benzylidene)acetone(CAS DataBase Reference)
• NIST Chemistry Reference: trans,trans-bis(4-(dimethylamino)benzylidene)acetone(98303-49-2)
• EPA Substance Registry System: trans,trans-bis(4-(dimethylamino)benzylidene)acetone(98303-49-2)

Safety Data

• Hazardous Substances Data: 98303-49-2(Hazardous Substances Data)

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 30625-58-2 4-(4-N,N-dimethylaminophenyl)-3-buten-2-one 
• 67-64-1 acetone 

Downstream Products

• 2564-18-3 1-phenyl-3-((dimethylamino)styryl)-5-((dimethylamino)phenyl)-2-pyrazoline 
• 122252-46-4 bis (4-p-dimethylaminophenyl-2-pytazolin-3-yl) ketone 

Relevant articles and documents

Experimental and theoretical approach to the corrosion inhibition of mild steel in acid medium by a newly synthesized pyrazole carbothioamide heterocycle

Heterocyclic compound such as 3,5-disubstitued pyrazole carbothioamide was synthesized by cyclocondensation reaction between chalcone derivative and thiosemicarbazide as nucleophile substrate in ethanolic sodium hydroxide solution. The structure of synthe

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.

Synthesis of tetracyclic oxindoles and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity

A series of tetracyclic oxindole derivatives was synthesized by asymmetric 1, 3-dipole reaction in 2–4 steps in 57–86% overall yields. These compounds were evaluated for α-glucosidase inhibitory and glucose consumption-promoting activity in vitro. Compound 4l competitively and reversibly inhibited α-glucosidase (IC50 = 3.64 μM) with activity 14-fold higher than that of acarbose. Docking analysis substantiated these findings. In addition, compound 4l exhibited significant glucose consumption promoting activity at 1 μM.