98361-09-2

Upstream product

• 67920-85-8 <(1,2-dimethylethylenedioxy)phosphinyl>acetonitrile 
• 3376-23-6 C-phenyl-N-methylnitrone 
• 19521-13-2 α,β-dibromo-β-phenylpropionitrile 
• 74-89-5 methylamine 
• 4360-47-8 cinnamonitrile 
• 88286-26-4 α,β-dibromocinnamonitrile 

Downstream Products

• 960290-87-3 (2R,3S)-(-)-1-methyl-3-phenylaziridine-2-carboxamide 
• 88286-07-1 (2S,3S)-1-Methyl-3-phenyl-aziridine-2-carboxylic acid amide 
• 88286-14-0 2-N-methylamino-3-fluoro-3-phenylpropiononitrile 
• 88286-14-0 3-Fluoro-2-methylamino-3-phenyl-propionitrile 
• 88286-14-0 3-Fluoro-2-methylamino-3-phenyl-propionitrile 
• 88286-23-1 threo-2-N-methyl-3-fluoro-3-phenylalanine 
• 88286-23-1 erythro-2-N-methyl-3-fluoro-3-phenylalanine 
• 88286-23-1 2-N-methyl-3-fluoro-3-phenylalanine 
• 88286-18-4 threo-2-N-methylamino-3-fluoro-3-phenylpropionic acid amide 

Relevant academic research and scientific papers

Thermal Transformation of Alkenoylated Aziridines into Ring-Fused Pyrrolidines

3-Phenyl- and 3-unsubstituted-2-alkenoyl-1-methylaziridines have been synthesized via Grignard reactions with the corresponding 2-cyanoaziridines.The 3-phenylated-2-alkenoylaziridines have been thermally transformed into ring-fused pyrrolidine compounds.The configurations and conformations of the aziridine and pyrrolidine compounds have been determined by 1H and 13C NMR spectroscopy and X-ray crystallography.

Reaction of Hydrogen Fluoride in Pyridine Solution with cis-Cyano-2- and cis-Amido-2-aziridines. Preparation of β-Fluoro-α-amino Acids and Esters by Means of Acidic Hydrolysis and Alcoholysis of β-Fluoro-α-Amino Nitriles and/or β-Fluoro-α-Amino Acid Amide

The addition of hydrogen fluoride generated from pyridinium poly(hydrogen fluoride) (i.e.Olah's reagent) to some cis-2-cyano- and cis-2-amido-aziridines has been examined.The reaction led to fluoroamine derivatives which upon acidic hydrolysis and alcohol

Nitrones. 6. Reactions of Nitrones with Cyclic Phosphonates. Influence of the Phosphonate Ring Size upon the Course of the Reaction

Nitrones, 5,5-dimethyl-Δ1-pyrroline N-oxide (5), and 3,4-dihydroisoquinoline N-oxide (6) were reacted with the five-membered cyclic phosphonates 2--2-oxo-4,5-dimethyl-1,3,2-dioxaphospholane (1) and 2-(cyanomethyl)-2-oxo-4,5-dimethyl-1,3,2-dioxaphospholane (2) and with the six-membered cyclic phosphonates 2--2-oxo-5,5-dimethyl-1,3,2-dioxaphosphorinane (3) and 2-(cyanomethyl)-2-oxo-5,5-dimethyl-1,3,2-dioxaphosphorinane (4).The reactions of the five-membered phosphonates gave aziridines as products, except that of 6 and 2.The reactions of the six-membered phosphonates gave exclusively or predominantly enamines.The reactions of C-phenyl-N-methylnitrone (7) with 2 gave only trans-1-methyl-2-cyano-3-phenylaziridine (22).Cyclic phosphates 2-hydroxy-2-oxo-4,5-dimethyl-1,3,2-dioxaphospholane (20) and 2-hydroxy-2-oxo-5,5-dimethyl-1,3,2-dioxaphosphorinane (21) were isolated as byproducts from the reactions of the corresponding phosphonates.