Thermal Transformation of Alkenoylated Aziridines into Ring-Fused Pyrrolidines

Article abstract of DOI:10.1021/jo00221a029

3-Phenyl- and 3-unsubstituted-2-alkenoyl-1-methylaziridines have been synthesized via Grignard reactions with the corresponding 2-cyanoaziridines.The 3-phenylated-2-alkenoylaziridines have been thermally transformed into ring-fused pyrrolidine compounds.The configurations and conformations of the aziridine and pyrrolidine compounds have been determined by 1H and 13C NMR spectroscopy and X-ray crystallography.