98464-79-0

Upstream product

• 21998-30-1 3-(4-chlorophenyl)-3-phenylpropanoic acid 
• 55010-16-7 3,3-bis(p-chlorophenyl)-propionic acid chloride 
• 71-43-2 benzene 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 65565-13-1 3-(4-chlorophenyl)-3-hydroxy-3-phenylpropanoic acid 
• 1379674-58-4 1-(4-chlorobenzyl)-2-ethynylbenzene 
• 2142-69-0 2-bromophenyl methyl ketone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 1247123-27-8 C₁₅H₁₀BrClO 
• 19936-83-5 2-Chlor-3-(4-chlor-phenyl)-indenon-⁽¹⁾ 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 1610735-43-7 1-((4-chlorophenyl)(methoxy)methyl)-2-ethynylbenzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

different nuclear ruthenium palladium double-ring metal compound and its preparation method and application

The invention discloses a heteronuclear ruthenium palladium bicyclic metal compound and a preparation method and an application thereof and belongs to the technical field of organic synthesis. The metal compound is easily prepared and modified, stable in

Palladium-catalyzed asymmetric reductive Heck reaction of aryl halides

Asymmetric reductive Heck reaction of aryl halides is realized in high stereoselectivity. Hydrogen-bond donors, trialkylammonium salts in a glycol solvent, were used to promote halide dissociation from neutral arylpalladium complexes to access cationic, stereoselective pathways.

Gold-catalyzed carboalkoxylations of 2-ethynylbenzyl ethers to form 1- and 2-indanones chemoselectively: Effects of ligands and solvents

The selective syntheses of 1- and 2-indan-one compounds from 2-ethynylbenzyl ethers have been achieved with suitable catalysts and solvents. The highly acidic [tris(pentafluorophenyl)phos-phine]gold hexafluoroantimonate [(C6F5)3AuSbF6] in nitromethane (MeNO2) preferably gives 1-indan-ones whereas [(ortho-biphenyl) di(tert-butyl)phosphine] gold triflimide [(tBu)2(o-biphenyl) AuNTf2] in dichloroethane tends to form 2-indanone derivatives. For 2-indanone products, we isolated two indenyl methyl ethers for deuterium labeling analyses, providing evidence for p-alkyne activation.

Superacid-promoted dual C-C bond formation by Friedel-Crafts alkylation and acylation of ethyl cinnamates: Synthesis of indanones

A superacid (triflic acid) promoted dual C-C bond formation via intermolecular Friedel-Crafts alkylation (Michael addition type) and intramolecular acylation for the efficient synthesis of 3-substituted indan-1-ones is presented. This method was successful in activating ethyl cinnamates towards dual aromatic electrophilic substitution. Moreover, it enabled us to synthesize novel spirotetracyclic systems. Georg Thieme Verlag Stuttgart · New York.

Gold-catalyzed oxidative cyclizations of cis-3-En-1-ynes to form cyclopentenone derivatives

Golden tendencies: The title reaction for synthesizing cyclopentenone derivatives utilizes a gold complex and 8-methylquinoline oxide as the catalyst system (see scheme; IPr=1,3-bis(diisopropylphenyl)imidazol-2-ylidene). Such products are not attainable using diazocarbonyl reagents, as the gold carbenoids tend to react with C-H bonds. Copyright

BTISA-catalyzed Friedel-Crafts bimolecular cyclization of cinnamic acid under superelectrophilic solvation conditions

Friedel-Crafts bimolecular cyclizations of cinnamic acid and cinnamoyl chloride with aromatic compounds in strong and superstrong acids in present of 1 mol% BTISA were investigated. It was demonstrated that catalytic amounts of this new superacid have essential effect on such type of reactions. Its use makes possible the preparation of indanones with quantitative yields.

Superacid-Catalyzed Reactions of Cinnamic Acids and the Role of Superelectrophiles

The chemistry of cinnamic acids and related compounds has been studied. In superacid-catalyzed reactions with arenes, two competing reaction mechanisms are proposed. Both mechanisms involve the formation of dicationic intermediates (superelectrophiles), and the reactions can lead to either chalcone-type products or indanone products. The direct observation of a dicationic species (by low-temperature 13C NMR) is reported. We provide clear evidence that protonated carboxylic acid groups (or the corresponding acyl cation) can enhance the reactivity of an adjacent electrophilic center. Triflic acid is also found to be an effective acid catalyst for the direct synthesis of some electron-deficient chalcones and heterocyclic chalcones from cinnnamic acids.

AMINO SUBSTITUTED BENZO(HETERO)CYCLIC DERIVATIVES

Use of compounds Formula (I), A = a 5- to 7-membered ring which may contain 1-3 heteroatoms and which may be saturated or partially or completely unsaturated; R= OH, SH, NH2, CN, NO2, halogen, C1-C6-alkyl, C1-C6-haloalkyl; C1-C6- alkoxy, C1-C6-haloalko

3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake

A series of 3-phenyl-1-indanamines was synthesized and tested for potential antidepressant activity and for inhibition of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) uptake. Transisomers were generally potent inhibitors of DA, NE, and 5-HT up