98556-09-3

Basic information

• Product Name: N-(2-broMo-5-nitrophenyl)forMaMide
• Synonyms: N-(2-broMo-5-nitrophenyl)forMaMide
• CAS NO: 98556-09-3
• Molecular Formula: C₇H₅BrN₂O₃
• Molecular Weight: 245.0302
• Mol File: 98556-09-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-broMo-5-nitrophenyl)forMaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-broMo-5-nitrophenyl)forMaMide(98556-09-3)
• EPA Substance Registry System: N-(2-broMo-5-nitrophenyl)forMaMide(98556-09-3)

Safety Data

• Hazardous Substances Data: 98556-09-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-bromo-5-nitrophenyl)formamide serves as an essential reagent in the synthesis of a range of pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting inflammation and oxidative stress.
Used in Agricultural Chemicals:
In the agricultural sector, N-(2-broMo-5-nitrophenyl)forMaMide is utilized in the production of various agrochemicals. Its role in this industry is pivotal for creating effective solutions to protect crops and enhance agricultural productivity.
Used as an Anti-inflammatory Agent:
Due to its observed anti-inflammatory properties, N-(2-bromo-5-nitrophenyl)formamide is studied for its potential therapeutic applications in treating conditions characterized by inflammation.
Used as an Antioxidant:
The antioxidant capabilities of N-(2-broMo-5-nitrophenyl)forMaMide have positioned it as a candidate for research into treatments for diseases where oxidative stress plays a significant role.
Used in Dye Intermediates:
N-(2-bromo-5-nitrophenyl)formamide is also considered in the dye industry, where it may be used as an intermediate for creating a variety of dyes with specific color characteristics.
Used in Polymer Production:
Its potential application in the production of polymers is another area of interest, where it could contribute to the development of new materials with specialized properties for various industrial applications.

Upstream product

• 64-18-6 formic acid 
• 10403-47-1 2-bromo 5-nitroaniline 

Downstream Products

• 2942-07-6 5-nitrobenzothiazole 
• 1123-93-9 5-aminobenzothiazole 
• 36894-61-8 N-(benzo[d]thiazol-5-yl)acetamide 
• 36894-62-9 N-phenylbenzo[d]thiazol-5-amine 
• 945912-69-6 N-(2-bromo-5-nitrophenyl)formimidoyl dichloride 

Relevant articles and documents

Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis

A previous publication from this lab (Patrick, et al. Bioorg. Med. Chem. 2016, 24, 2451-2465) explored the antitrypanosomal activities of novel derivatives of 2-(2-benzamido)ethyl-4-phenylthiazole (1), which had been identified as a hit against Trypanosoma brucei, the causative agent of human African trypanosomiasis. While a number of these compounds, particularly the urea analogues, were quite potent, these molecules as a whole exhibited poor metabolic stability. The present work describes the synthesis of 65 new analogues arising from medicinal chemistry optimization at different sites on the molecule. The most promising compounds were the urea derivatives of 2-aryl-benzothiazol-5-amines. One such analogue, (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole (57) was chosen for in vivo efficacy studies based upon in vitro activity, metabolic stability, and brain penetration. This compound attained 5/5 cures in murine models of both early and late stage human African trypanosomiasis, representing a new lead for the development of drugs to combat this neglected disease.

COMPOUNDS FOR TREATMENT OF TRYPANOSOMES AND NEUROLOGICAL PATHOGENS AND USES THEREOF

The present invention relates to novel compounds that cross the blood-brain barrier and are effective inhibitors of neurological pathogens such as trypanosomes. The invention further relates to the use of these compounds for treating disorders related to trypanosomes and neurological pathogens.