36894-61-8

Usage

InChI:InChI=1/C9H8N2OS/c1-6(12)11-7-2-3-9-8(4-7)10-5-13-9/h2-5H,1H3,(H,11,12)

Upstream product

• 1123-93-9 5-aminobenzothiazole 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 64-18-6 formic acid 
• 431-03-8 dimethylglyoxal 
• 76209-01-3 4-acetylamino-2-nitrobenzenethiol 
• 108018-02-6 3'-amino-4'-mercaptoacetanilide 
• 123-06-8 Ethoxymethylenemalononitrile 
• 98556-09-3 N-(2-bromo-5-nitrophenyl)formamide 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 58759-63-0 5-nitrobenzo[d]thiazole-2(3H)-thione 
• 2942-07-6 5-nitrobenzothiazole 

Downstream Products

• 36894-62-9 N-phenylbenzo[d]thiazol-5-amine 

Relevant academic research and scientific papers

Iodine-promoted ring-opening methylation of benzothiazoles with dimethyl sulfite

A halogen-bond promoted ring-opening methylation of benzothiazoles has been developed using dimethyl sulphite as a methylating reagent in the presence of a base. This approach represents a simple and efficient synthesis ofN-methyl-N-(o-methylthio)phenyl amides, and features direct construction of both N-Me and S-Me bonds in a one-pot reaction through the decomposition of easily prepared benzothiazoles.

Catalyst-free generation of acyl radicals induced by visible light in water to construct C-N bonds

We describe herein a catalyst-free and redox-neutral photochemical strategy for the direct generation of acyl radicals from α-diketones, and its selective conversion of nitrosoarenes to hydroxyamides or amides with AcOH or NaCl as an additive. The reaction was carried out under mild conditions in water with purple LEDs as the light source. A broad scope of substrates was demonstrated. Mechanistic experiments indicate that α-diketones cleave to give acyl radicals, with hydroxyamides being further reduced to amides.

HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. In certain embodiments, the compounds are thiazolidinone derivatives.