98717-15-8

Basic information

• Product Name: Ropivacaine hydrochloride
• Synonyms: ROPIVCACAINE HYDROCHLORIDE;ROPIVACAINE HCL;(S)-ROPIVACAINE HYDROCHLORIDE;S-ROPIVACAINE HCL;n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide hydrochloride;Ropivacaine mesilate;Ropivacaine hydrochloride;(2S)-N-(2,6-dimethylphenyl)-1-propyl-pipecolinamide hydrochloride
• CAS NO: 98717-15-8
• Molecular Formula: C₁₇H₂₆N₂O*ClH
• Molecular Weight: 310.86
• EINECS: 1312995-182-4
• Product Categories: Active Pharmaceutical Ingredients;Anesthetic (Local)
• Mol File: 98717-15-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 260-262°
• Boiling Point: 436.7 °C at 760 mmHg
• Flash Point: 217.9 °C
• Appearance: /
• Density: 1.044 g/cm³
• Vapor Pressure: 4.37E-08mmHg at 25°C
• CAS DataBase Reference: Ropivacaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ropivacaine hydrochloride(98717-15-8)
• EPA Substance Registry System: Ropivacaine hydrochloride(98717-15-8)

Safety Data

• Hazardous Substances Data: 98717-15-8(Hazardous Substances Data)

Usage

Uses

2-Piperidinecarboxamide hydrochloride is a useful research chemical compound.

Definition

ChEBI: The anhydrous form of (S)-ropivacaine hydrochloride.

InChI:InChI=1/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H

Upstream product

• 926275-68-5 (S)-1-propylpiperidine-2-carboxylic acid 
• 4043-87-2 pipecolic Acid 
• 87-62-7 2,6-dimethylaniline 
• 3105-95-1 pipecolinic acid 
• 1236222-96-0 propyl (1-propylpiperidine)-2-carboxylate 
• 84057-95-4 ropivacaine 
• 65797-42-4 (+/-)-2',6'-pipecoloxylidide hydrochloride 
• 106-94-5 propyl bromide 

Downstream Products

• 132112-35-7 ropivacaine hydrochloride monohydrate 
• 84057-95-4 ropivacaine 

Relevant articles and documents

Method for preparing ropivacaine hydrochloride

The preparation method comprises the following specific steps: 1) reacting (S)- piperidine -2 - formic acid with propionaldehyde in the presence of a reducing agent and an aprotic solvent to obtain the intermediate 1. 2). N. NIn the presence of -dimethylformamide and an aprotic solvent, the intermediate 1 obtained in step 1) and the acylating agent are subjected to an acylation reaction to give an intermediate 2. 3). N. N[-] The intermediate 2 obtained in step 2) and 2 and 6 -dimethylaniline are subjected to a condensation reaction in the presence of dimethylformamide and basic conditions to give an intermediate 3. 4) The intermediate 3 obtained in step 3) is salified with hydrochloric acid to give the ropivacaine hydrochloride crude product. 5) The ropivacaine hydrochloride is purified to obtain ropivacaine hydrochloride. The method has the advantages that the product purity is higher than 99.99%, the synthesis process is mild in reaction condition, simple in preparation process, low in cost, safe and environment-friendly, and is suitable for industrial production.

Preparation method of ropivacaine hydrochloride

The invention discloses a preparation method of ropivacaine hydrochloride. The preparation method comprises steps as follows: (1) preparation of an intermediate (I), (2) preparation of an intermediate (II), (3) preparation of a crude product and (4) refin

PROCESS FOR PRODUCING OPTICALLY ACTIVE N-ALKYL-PIPERIDINE-2-CARBOXANILIDE

Disclosed herein is a process for producing optically active 1-n-propyl-2',6'-dimethyl-2-piperidinecarboxanilide. The process comprises of reacting n-propyl pipecolate ester with 2,6-dimethylanilino magnesium halide. The 1-n-propyl-2',6'-dimethyl-2-piperi