98754-18-8

Upstream product

• 76857-06-2 1-benzylspiro-4'-one 
• 79098-91-2 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79098-90-1 1-benzyl-4-[N-(o-aminomethylphenyl)-amino]-piperidine 
• 28144-70-9 anthranilic acid amide 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 98754-22-4 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 

Relevant academic research and scientific papers

Synthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents

A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.