98754-22-4

Basic information

• Product Name: 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one
• Synonyms: 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one
• CAS NO: 98754-22-4
• Molecular Weight: 385.893
• Mol File: 98754-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one(98754-22-4)
• EPA Substance Registry System: 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one(98754-22-4)

Safety Data

• Hazardous Substances Data: 98754-22-4(Hazardous Substances Data)

Upstream product

• 76857-06-2 1-benzylspiro-4'-one 
• 79098-91-2 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 98754-18-8 1-{1-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 
• 79098-90-1 1-benzyl-4-[N-(o-aminomethylphenyl)-amino]-piperidine 
• 28144-70-9 anthranilic acid amide 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Relevant articles and documents

Synthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents

A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.