79098-91-2

Usage

Chemical class

Piperidine derivatives

Type of compound

Heterocyclic compound

Potential pharmacological activities

Neurological and psychiatric disorders treatment

Structure

Contains a piperidine ring and a quinazolinone ring

Importance

Crucial for biological activity

Significance in research

Medicinal chemistry and drug development

Potential therapeutic properties

Treatment of neurological and psychiatric disorders

Upstream product

• 79098-90-1 1-benzyl-4-[N-(o-aminomethylphenyl)-amino]-piperidine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 28144-70-9 anthranilic acid amide 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 76857-06-2 1-benzylspiro-4'-one 

Downstream Products

• 98754-24-6 threo-1-<2-acetoxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79106-38-0 threo-1-<2-hydroxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79106-37-9 1-<2-oxo-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-1-quinazolinyl)piperidine 
• 79106-35-7 1-{1-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 
• 79106-33-5 1-(3,4-dimethoxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-1-yl]-piperidine 
• 98754-22-4 1-{1-[2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 
• 98754-18-8 1-{1-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one 

Relevant academic research and scientific papers

DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS

Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach

A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement

4-Heterocyclic peperidines promote release of growth hormone

The present invention is directed to certain novel compounds identified as 4-heterocycle substituted piperidines of the general structural formula: STR1 wherein R1, R4, R5, A, R3 and the dashed line are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

Synthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents

A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.

Piperidine derivatives and pharmaceutical compositions containing same

A new piperidine derivative represented by the formula: STR1 wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); m and n are 0 or 1, and are