99045-18-8

Usage

Uses

Used in Pharmaceutical Industry:
5-BroMo-1,3-Difluoro-2-(PhenylMethoxy)-Benzene is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical industry, 5-BroMo-1,3-Difluoro-2-(PhenylMethoxy)-Benzene serves as an intermediate in the production of agrochemicals. Its presence in these compounds can help improve the effectiveness of pesticides, herbicides, and other agricultural products, ultimately contributing to increased crop yields and more sustainable farming practices.
Used as a Reagent in Organic Chemical Reactions:
5-BroMo-1,3-Difluoro-2-(PhenylMethoxy)-Benzene is also utilized as a reagent in various organic chemical reactions. Its versatility and unique functional groups make it a valuable tool for chemists in the synthesis of complex organic molecules, further expanding its applications across different fields of chemistry.

Upstream product

• 100-44-7 benzyl chloride 
• 104197-13-9 4-bromo-2,6-difluorophenol 
• 100-39-0 benzyl bromide 
• 28177-48-2 2,6-difluorophenol 

Downstream Products

• 1255041-73-6 C₁₉H₂₁BF₂O₃ 
• 1181566-68-6 1-(3,5-difluoro-4-hydroxyphenyl)-1H-indol-4-ol 
• 1224103-92-7 (E)-3-(4-benzyloxy-3,5-difluorophenyl)-2-methylacrylic acid ethyl ester 
• 125036-88-6 4-(benzyloxy)-3,5-difluorobenzaldehyde 
• 947279-23-4 3-(benzyloxy)-2,4-difluorobenzaldehyde 
• 1224103-93-8 3-(3,5-difluoro-4-hydroxyphenyl)-2-methylpropionic acid ethyl ester 
• 1042702-84-0 C₁₅H₁₂F₂O₂ 
• 1042702-90-8 C₂HF₃O₂*C₁₂H₁₃F₂NO₄ 
• 1042702-88-4 C₂₄H₂₇F₂NO₆ 
• 1042702-86-2 C₁₅H₁₁BrF₂O₂ 
• 1181567-01-0 1-{3,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole 
• 301185-51-3 4-Hydroxy-4-(3-(3,5-difluoro-4-hydroxyphenyl)propyl)piperidine.HCl 

Relevant academic research and scientific papers

Novel phenolic compound and preparation method and application thereof

The invention provides a novel phenolic compound and a preparation method and application thereof. The chemical general formula of the novel phenolic compound is as shown in formula (1), and R is Br,Cl or F. According to the novel phenolic compound, the growth of gram-positive bacteria can be obviously inhibited, the minimum inhibitory concentration on staphylococcus aureus, bacillus and methicillin-resistant staphylococcus aureus is 1-4mu g/mL, the drug resistance is not generated under long-time low-dose exposure, and the compound can be used as a gram-positive bacteria antibacterial agentand has a good antibacterial effect.

Structure Property Relationships of Carboxylic Acid Isosteres

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical strategy in medicinal chemistry. The general underlying principle is that by maintaining the features of the carboxylic acid critical for biological activity, but appropriately modifying the physicochemical properties, improved analogs may result. In this context, a systematic assessment of the physicochemical properties of carboxylic acid isosteres would be desirable to enable more informed decisions of potential replacements to be used for analog design. Herein we report the structure-property relationships (SPR) of 35 phenylpropionic acid derivatives, in which the carboxylic acid moiety is replaced with a series of known isosteres. The data set generated provides an assessment of the relative impact on the physicochemical properties that these replacements may have compared to the carboxylic acid analog. As such, this study presents a framework for how to rationally apply isosteric replacements of the carboxylic acid functional group.

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

SUBSTITUTED PHENYLLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted phenylureas and phenylamides of formula (I), to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.

SUBSTITUTED 4-HYDROXY-N- (4-HYDROXYPHENYL) INDOLES AS ESTROGENIC AGENTS

The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.

Pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula 1: (wherein R1, R2, R3, R4, R5, R6and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.

Certain 3,5-disubstituted-2-pyridyloxy-fluorophenoxy-alkanoic acids, derivatives thereof and herbicidal properties

Certain novel fluorophenoxy compounds, principally aryloxyfluorophenoxyalkanoic acids and derivatives thereof, are described. More specifically, these novel compounds bear 1 to 4 fluorine substituents on the phenyl ring. These novel compounds exhibit surprising preemergent and postemergent activity when used according to the method of the invention in the control of grassy weeds.