99048-57-4

Upstream product

• 99048-68-7 (4E,6E)-7-(4-Methoxy-phenyl)-1,1-bis-methylsulfanyl-hepta-1,4,6-trien-3-ol 
• 1963-36-6 4-methoxycinnamaldehyde 
• 137612-33-0 (4E,6E)-7-(4-Methoxy-phenyl)-1,1-bis-methylsulfanyl-hepta-1,4,6-trien-3-one 
• 130248-53-2 (E)-4-(4-methoxyphenyl)-1-(trimethylsilyl)but-3-en-1-yne 
• 23517-07-9 ((E)-1-(but-1-en-3-yn-1-yl)-4-methoxybenzene) 
• 292638-85-8 acrylic acid methyl ester 
• 67-56-1 methanol 

Relevant academic research and scientific papers

Microwave-accelerated Ru-catalyzed hydrovinylation of alkynes and enynes: A straightforward approach toward 1,3-dienes and 1,3,5-trienes

Quick, but not dirty! Microwave heating was found to have a significant effect on the Ru-catalyzed hydrovinylations of alkynes. A broad range of different terminal alkynes were coupled to methyl acrylate within just 30min in good to excellent yields (see scheme). This new protocol was transferred to the hydrovinylation of enynes as novel coupling partners in C-H-activation chemistry giving different 1,3,5-trienes as the sole products. Copyright

A new 1,5- to 1,11-carbonyl transposition protocol involving ketene dithioacetal chemistry: An efficient polyene synthesis

An efficient strategy for alternative 1,5-, 1,7-, 1,9- and 1,11- carbonyl transposition has been developed via 1,2-reductive or alkylative addition to 5,5-bis(methylthio)-2,4-pentadienals 3a-b, 7,7-bis(methylthio)-2,4,6-heptatrienones 5,9,9-bis(methylthio)-2,4,6,8-nonatetraenones 8 and 11,11-bis(methylthio)-2,4,6,8,10-undecapentaenones 11 followed by BF3,Et2O induced methanolysis of the resulting carbinols to the corresponding polyene esters. The synthesis of the novel polyene aldehydes 3a-b, 7a-b, 10b and polyenones 5, 8, 11 precursors has also been described following iterative Vielsmeier-Haack reaction and aldol condensation.