130248-53-2

Basic information

• Product Name: (E)-4-(4-methoxyphenyl)-1-(trimethylsilyl)but-3-en-1-yne
• Synonyms: (E)-4-(4-methoxyphenyl)-1-(trimethylsilyl)but-3-en-1-yne
• CAS NO: 130248-53-2
• Molecular Weight: 230.382
• Mol File: 130248-53-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-4-(4-methoxyphenyl)-1-(trimethylsilyl)but-3-en-1-yne(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(4-methoxyphenyl)-1-(trimethylsilyl)but-3-en-1-yne(130248-53-2)
• EPA Substance Registry System: (E)-4-(4-methoxyphenyl)-1-(trimethylsilyl)but-3-en-1-yne(130248-53-2)

Safety Data

• Hazardous Substances Data: 130248-53-2(Hazardous Substances Data)

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 1066-54-2 trimethylsilylacetylene 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 27570-08-7 4-(2-bromo-vinyl)-anisole 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 6303-59-9 (E)-4-(2-bromo-vinyl)-anisole 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 161944-19-0 Trimethyl-((E)-4-phenylsulfanyl-but-3-en-1-ynyl)-silane 
• 136618-41-2 E-2'-p-methoxystyryl iodide 
• 14630-40-1 Bis(trimethylsilyl)ethyne 

Downstream Products

• 99048-57-4 methyl (2E,4E,6E)-7-((p-methoxy)phenyl)hepta-2,4,6-trienoate 
• 23517-07-9 ((E)-1-(but-1-en-3-yn-1-yl)-4-methoxybenzene) 

Relevant articles and documents

Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a π-Acceptor Biphosphoramidite Ligand

The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important E-(poly)enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.

Triazole-curcuminoids: A new class of derivatives for 'tuning' curcumin bioactivities?

Curcumin is a unique blend of pharmacophores responsible for the pleiotropy of this natural pigment. In the present study we have replaced the 1,3-dicarbonyl moiety with a 1,2,3-triazole ring to furnish a new class of triazole-curcuminoids as a possible strategy to generate new compounds with different potency and selectivity compared to curcumin. We obtained a proof-of-principle library of 28 compounds tested for their cytotoxicity (SY-SY5Y and HeLa cells) and for their ability to inhibit NF-κB. Furthermore, we also generated 1,3-dicarbonyl curcuminoids of selected click compounds. Triazole-curcuminoids lost their ability to be Michael's acceptors, yet maintained some of the features of the parent compounds and disclosed new ones. In particular, we found that some compounds were able to inhibit NF-κB without showing cytotoxicity, while others, unlike curcumin, activated NF-κB signalling. This validates the hypothesis that click libraries can be used to investigate the biological activities of curcumin as well as generate analogs with selected features.

(Z)-Selective cross-dimerization of arylacetylenes with silylacetylenes catalyzed by vinylideneruthenium complexes

The vinylideneruthenium(II) complexes bearing bulky and basic tertiary phosphine ligands, RuCl2(=C=CHPh)L2 (L = PPr i3, PCy3), serves as a good catalyst precursor for (Z)-selective cross-dimerization between arylacetylenes and silylacetylenes in the presence of N-methylpyrrolidine. The Royal Society of Chemistry 2005.