130248-53-2Relevant academic research and scientific papers
Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a π-Acceptor Biphosphoramidite Ligand
Zhao, Jiangui,Zheng, Xueli,Tao, Shaokun,Zhu, Yuxin,Yi, Jiwei,Tang, Songbai,Li, Ruixiang,Chen, Hua,Fu, Haiyan,Yuan, Maolin
, p. 6067 - 6072 (2021/08/16)
The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important E-(poly)enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.
Photochemical Cobalt-Catalyzed Hydroalkynylation to Form 1,3-Enynes
Grenier-Petel, Jean-Christophe,Collins, Shawn K.
, p. 3213 - 3218 (2019/04/13)
A photochemical hydroalkynylation is reported employing a metallaphotoredox approach using cobalt catalysis and an organic dye, 4CzIPN. The protocol enables catalysis without the need for stoichiometric metal reductants, normally needed to convert higher
Triazole-curcuminoids: A new class of derivatives for 'tuning' curcumin bioactivities?
Caprioglio, Diego,Torretta, Simone,Ferrari, Maila,Travelli, Cristina,Grolla, Ambra A.,Condorelli, Fabrizio,Genazzani, Armando A.,Minassi, Alberto
, p. 140 - 152 (2015/12/31)
Curcumin is a unique blend of pharmacophores responsible for the pleiotropy of this natural pigment. In the present study we have replaced the 1,3-dicarbonyl moiety with a 1,2,3-triazole ring to furnish a new class of triazole-curcuminoids as a possible strategy to generate new compounds with different potency and selectivity compared to curcumin. We obtained a proof-of-principle library of 28 compounds tested for their cytotoxicity (SY-SY5Y and HeLa cells) and for their ability to inhibit NF-κB. Furthermore, we also generated 1,3-dicarbonyl curcuminoids of selected click compounds. Triazole-curcuminoids lost their ability to be Michael's acceptors, yet maintained some of the features of the parent compounds and disclosed new ones. In particular, we found that some compounds were able to inhibit NF-κB without showing cytotoxicity, while others, unlike curcumin, activated NF-κB signalling. This validates the hypothesis that click libraries can be used to investigate the biological activities of curcumin as well as generate analogs with selected features.
Phosphine-dependent selective cross-dimerization between terminal alkylacetylene and silylacetylene by iridium(I) guanidinate complex-phosphine system
Ogata, Kenichi,Oka, Oji,Toyota, Akinori,Suzuki, Noriyuki,Fukuzawa, Shin-Ichi
experimental part, p. 2663 - 2666 (2009/04/11)
The new iridium(I)-guanidinate complex served as an efficient catalyst for phosphine-dependent selective cross-dimerization between silylacetylene and terminal alkyl- or arylacetylene. Especially, in case of cross-dimerization between silylacetylene and alkylacetylene, E/Z selectivity of resulting enynes could be controlled by changing phosphine.
(Z)-Selective cross-dimerization of arylacetylenes with silylacetylenes catalyzed by vinylideneruthenium complexes
Katayama, Hiroyuki,Yari, Hiroshi,Tanaka, Masaki,Ozawa, Fumiyuki
, p. 4336 - 4338 (2008/02/08)
The vinylideneruthenium(II) complexes bearing bulky and basic tertiary phosphine ligands, RuCl2(=C=CHPh)L2 (L = PPr i3, PCy3), serves as a good catalyst precursor for (Z)-selective cross-dimerization between arylacetylenes and silylacetylenes in the presence of N-methylpyrrolidine. The Royal Society of Chemistry 2005.
A straightforward synthesis of symmetrical polyendiynes by dimerization reactions of silyl derivatives
Babudri, Francesco,Fiandanese, Vito,Marchese, Giuseppe,Punzi, Angela
, p. 251 - 257 (2007/10/03)
A straightforward synthesis of polyendiynes is described. The method is based upon a simple dimerization reaction of silylated enynes in the presence of copper salts. A variety of polyunsaturated compounds have been obtained in high yields and with high retention of configuration.
A new synthesis of substituted fulvenes
Lee, Gary C. M.,Tobias, Brian,Holmes, Judy M.,Harcourt, Dale A.,Garst, Michael E.
, p. 9330 - 9336 (2007/10/02)
A new fulvene synthesis results from the palladium-catalyzed [2 + 2 + 2] annulation of 1 mol of a β-substituted vinyl iodide and 2 mol of a monosubstituted acetylene. This variant of the Heck reaction tolerates a wide range of substrate substituents with
