99059-14-0

Basic information

• Product Name: 3-(3-formyl-4-hydroxyphenyl)propanoic acid
• Synonyms: 3-(3-formyl-4-hydroxyphenyl)propanoic acid
• CAS NO: 99059-14-0
• Molecular Weight: 194.187
• Mol File: 99059-14-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(3-formyl-4-hydroxyphenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-formyl-4-hydroxyphenyl)propanoic acid(99059-14-0)
• EPA Substance Registry System: 3-(3-formyl-4-hydroxyphenyl)propanoic acid(99059-14-0)

Safety Data

• Hazardous Substances Data: 99059-14-0(Hazardous Substances Data)

Upstream product

• 100-97-0 hexamethylenetetramine 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 67-66-3 chloroform 

Relevant articles and documents

Towards novel biolabels: Synthesis of a tagged highly fluorescent Schiff-base aluminium complex

Starting from 3-(4-hydroxyphenyl)propanoic acid, formylation ortho to the phenol and condensation with ortho-aminophenol gave a novel functionalised Schiff-base ligand. Formation of the N-hydroxysuccinimidyl ester and non-aqueous complexation with AlEt2Cl gave a novel fluorescent biolabel displaying a Stokes shift of 100 nm. The efficacy of the new system was demonstrated by its attachment to rabbit IgG.

COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF

Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

Inhibitors of protein kinase for the treatment of disease

The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.