99110-77-7

Upstream product

• 4097-89-6 2,2',2''-triaminotriethylamine 
• 95215-72-8 2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetic acid 
• 84719-32-4 3-Hydroxy-2(1H)-pyridinone 
• 100-44-7 benzyl chloride 
• 95215-70-6 1-ethoxycarbonylmethyl-3-hydroxy pyrid-2-one 
• 95215-73-9 3-(benzyloxy)-1-<<(succinimidyloxy)carbonyl>methyl>-2(1H)-pyridinone 

Downstream Products

• 99110-76-6 N,N,N-tris<2-(3-hydroxy-2-oxo-1,2-dihydropyridin-1-yl)acetamido>ethylamine 

Relevant academic research and scientific papers

Synthesis, physico-chemical and iron(III)-chelating properties of novel hexadentate 3-hydroxy-2(1H)pyridinone ligands

Synthesis of hexadentate ligands via the in situ formation of 1-hydroxy benzotriazolyl active ester in the presence of 2-(1H-benzotriazol-1-yl)- 1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU as a coupling agent is described. The pKa values and distri

Novel 3-hydroxy-2(1H)-pyridinones. Synthesis, iron(III)-chelating properties, and biological activity

The synthesis of a range of novel bidentate and hexadentate ligands containing the chelating moiety 3-hydroxy-2(1H)-pyridinone is described. The pK(a) values of the ligands and the stability constants of their iron(III) complexes have been determined. The stability constant of the iron(III) complex of one of the hexadentate ligands is comparable to that of desferrioxamine B. The distribution coefficients of the ligands and their iron(III) complexes were also determined. One of the novel hexadentate compounds has been shown to markedly enhance iron(III) excretion from both hepatocytes and iron-overloaded mice.