99275-44-2Relevant academic research and scientific papers
Design and synthesis of azaindole heterocycle decorated new scaffold in fluorometric sensing of F? and H2PO4?
Ghosh, Kumaresh,Ali, Sk. Sarfaraj,Joardar, Soumen
, p. 3558 - 3565 (2020/08/06)
7-Azaindole has been used in designing new molecular structure 1 on enediyne spacer for its application in anion sensing. New structure 1 has been established as efficient fluorescent sensor of H2PO4? and F? ion
Heat Versus Basic Conditions: Intramolecular Dehydro-Diels-Alder Reaction of 1-Indolyl-1,6-heptadiynes for the Selective Synthesis of Substituted Carbazoles
Kudoh, Takayuki,Fujisawa, Syo,Kitamura, Megumi,Sakakura, Akira
, p. 2189 - 2193 (2017/09/26)
The intramolecular dehydro-Diels-Alder reaction of 1-indolyl-1,6-heptadiynes proceeds smoothly under rather mild heating conditions to give substituted carbazoles in moderate to good yields. The reaction of 7-aryl-1-indolyl-1,6-heptadiynes under heating gives the corresponding carbazoles chemoselectively in high yields, whereas the reaction under basic conditions gives naphthalenes as major products.
ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS
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Paragraph 00236, (2016/04/26)
Compounds of general formula I that are capable of inhibiting bacterial pyruvate kinase and/or bacterial growth. The compounds may find use as antibacterial agents in therapeutic and/or non- therapeutic contexts.
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections
Kumar, Nag S.,Dullaghan, Edie M.,Finlay, B. Brett,Gong, Huansheng,Reiner, Neil E.,Jon Paul Selvam,Thorson, Lisa M.,Campbell, Sara,Vitko, Nicholas,Richardson, Anthony R.,Zoraghi, Roya,Young, Robert N.
, p. 1708 - 1725 (2014/03/21)
A novel series of bis-indoles derived from naturally occurring marine alkaloid 4 were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK is not only critical for bacterial survival which
Azaindole-1,2,3-triazole conjugate as selective fluorometric sensor for dihydrogenphosphate
Ghosh, Kumaresh,Kar, Debasis,Joardar, Soumen,Sahu, Debashis,Ganguly, Bishwajit
, p. 16144 - 16151 (2013/09/12)
A new receptor 1 has been designed and synthesized. The open cavity of 1 selectively recognizes H2PO4- over a series of other anions in CH3CN containing 0.01% DMSO by exhibiting a ratiometric change in emission.
A convenient iodination of indoles and derivatives
Hamri, Salha,Rodríguez, Jose,Basset, Joan,Guillaumet, Gérald,Dolors Pujol
supporting information; experimental part, p. 6269 - 6275 (2012/08/28)
We report a direct iodination of indole and derivative compounds with iodine monochloride (ICl) in the presence of Celite. This procedure has now been extended to the iodination of substituted indoles, azaindoles and pyrroles. The scope of this procedure
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity
Leboho, Tlabo C.,Michael, Joseph P.,van Otterlo, Willem A.L.,van Vuuren, Sandy F.,de Koning, Charles B.
scheme or table, p. 4948 - 4951 (2009/12/24)
A series of 2- and 3-aryl substituted indoles and two 1,3,4,5-tetrahydropyrano[4,3-b]indoles were synthesized from indole and 5-methoxyindole. The 2-aryl indoles were synthesized from the 1-(phenylsulfonyl)indole derivatives using magnesiation followed by iodination. The 2-iodinated compounds were then subjected to Suzuki-Miyaura reactions. In addition, the 3-aryl indoles were made from the corresponding 3-bromoindoles using Suzuki-Miyaura reactions. The 1,3,4,5-tetrahydropyrano[4,3-b]indoles were also synthesized from 1-(phenylsulfonyl)indole by magnesiation followed by treatment with allylbromide. The product was then converted into [2-allyl-1-(phenylsulfonyl)-1H-indol-3-yl]methanol which upon exposure to Hg(OAc)2 and NaBH4 afforded tetrahydropyrano[4,3-b]indoles. A number of the 2- and 3-aryl indoles displayed noteworthy antimicrobial activity, with compound 13a displaying the most significant activity (3.9 μg/mL) against the Gram-positive micro-organism Bacillus cereus.
Fluorous synthesis of yuehchukene by α-lithiation of perfluoroalkyl-tagged 1-(arylsulfonyl)indole with mesityllithium
Naka, Hiroshi,Akagi, Yusuke,Yamada, Kyoko,Imahori, Tatsushi,Kasahara, Takahiro,Kondo, Yoshinori
, p. 4635 - 4637 (2008/03/12)
Lithiation chemistry has not been well explored in fluorous synthesis because of the lack of appropriate base-resistant fluorous tags; we recently developed a perfluoroalkylated arylsulfonyl tag for the protection of the indole ring nitrogen atom. Mesityl
A convenient synthesis of 2-nitroindoles
Roy, Sujata,Gribble, Gordon W.
, p. 1325 - 1328 (2007/10/03)
The reaction of 2-iodo- and 2-bromoindoles with silver nitrite in aqueous acetone affords the corresponding 2-nitroindoles in modest to good yields.
Benzannulation reactions of Fischer carbene complexes for the synthesis of indolocarbazoles
Merlic, Craig A.,You, Ying,McInnes, Daniel M.,Zechman, Andrea L.,Miller, Michael M.,Deng, Qiaolin
, p. 5199 - 5212 (2007/10/03)
The synthesis of indolocarbazoles was achieved via photochemical and thermal annulation reactions of chromium Fischer carbene complexes. This methodology allows for facile incorporation of hydrogen bonding functionality which complements the pharmacophore contained within bioactive indolocarbazole natural products.
