43002-54-6

Basic information

• Product Name: 4-(Hydroxymethyl)-2-phenyl-1H-imidazole
• Synonyms: (2-Phenyl-1H-imidazol-4-yl)methanol;4-(Hydroxymethyl)-2-phenyl-1H-imidazole;2-Phenyl-4-hydroxymethylimidazole;(2-Phenyl-1H-imidazol-5-yl)methanol;2-phenyl-1H-Imidazole-5-methanol
• CAS NO: 43002-54-6
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 43002-54-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 144-146
• Boiling Point: 438.665°C at 760 mmHg
• Flash Point: 219.097°C
• Appearance: /
• Density: 1.244g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.41±0.10(Predicted)
• CAS DataBase Reference: 4-(Hydroxymethyl)-2-phenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Hydroxymethyl)-2-phenyl-1H-imidazole(43002-54-6)
• EPA Substance Registry System: 4-(Hydroxymethyl)-2-phenyl-1H-imidazole(43002-54-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 43002-54-6(Hazardous Substances Data)

Usage

General Description

4-(Hydroxymethyl)-2-phenyl-1H-imidazole, also known as Ligustral, is a chemical compound often used in the field of chemistry for research and development purposes. Belonging to the group of imidazoles, this compound contains an aromatic five-membered ring within its structure. The presence of a hydroxymethyl (-CH2OH) group and a phenyl ring as substituents provide it with unique chemical properties and make it useful in a variety of applications. Its molecular formula is C11H10N2O, and it appears as an off-white or pale yellow crystalline solid. It is known to have a strong odor, similar to the smell of lily-of-the-valley flowers. It is commonly used in the fragrance industry and is also used as a material for organic synthesis.

InChI:InChI=1/C10H10N2O/c13-7-9-6-11-10(12-9)8-4-2-1-3-5-8/h1-6,13H,7H2,(H,11,12)

Upstream product

• 39978-59-1 ethyl 2-amino-3-hydroxypropanoate 
• 123-91-1 1,4-dioxane 
• 77498-98-7 2-phenyl-1H-imidazole-4-carboxylic acid 
• 62147-49-3 1,3-dihydroxyacetone dimer 
• 618-39-3 benzamidin 
• 96-26-4 dihydroxyacetone 
• 100-52-7 benzaldehyde 
• 1670-14-0 benzamidine monohydrochloride 

Downstream Products

• 68282-47-3 2-phenyl-1H-imidazole-4(5)-carboxaldehyde 
• 144649-74-1 2-phenyl-4-⁽⁵⁾-[(4-(2-methoxyphenyl)-piperazin-1-yl)-methyl]imidazole 
• 79047-40-8 2-phenyl-4-chloro-5-(hydroxymethyl)-imidazole 
• 68283-16-9 8-chloro-6-phenyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 
• 68283-01-2 6-phenyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 

Relevant articles and documents

New chiral and achiral imines and bisimines derived from 2-phenyl-1h-imidazole-4-carbaldehyde. Synthesis, structural studies and complexation stability constants

Synthesis and properties of new imines and bisimines derived from 2-phenyl-1H-imidazole-4-carbaldehyde and amines/diamines were studied. (2-Phenyl-1H-imidazole-4-yl)methanol was oxidized to 2-phenyl-1H-imidazole-4- carbaldehyde with better yield 55% by th

PYRROLOPYRIMIDINES AS CFTR POTENTIATORS

The present invention relates to compounds of Formula I, wherein R1a, R1b, R2, R3, R4, W, Y, and Z are as described herein, and pharmaceutically acceptable salts thereof. The compounds are potentiator

5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists

A series of ring-substituted analogues of imidazole-4-acetic acid (IAA, 4), a partial agonist at both GABAA and GABAC receptors (GABA = γ-aminobutyric acid), have been synthesized. The synthesized compounds 8a-1 have been evaluated a