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Usage

Uses

Used in Pharmaceutical Industry:
N-(4'-methoxybenzenesulphonyl)-L-glutamic acid is used as a reagent for the preparation of peptide-based drugs due to its ability to modify proteins and peptides, enhancing their therapeutic potential.
Used in Antimicrobial Applications:
N-(4'-methoxybenzenesulphonyl)-L-glutamic acid is used as an antimicrobial agent for its ability to combat various microorganisms, contributing to the development of new treatments for infectious diseases.
Used in Anticancer Applications:
N-(4'-methoxybenzenesulphonyl)-L-glutamic acid is used as an anticancer agent, potentially aiding in the development of new cancer therapies by leveraging its antimicrobial properties and its ability to modify peptides and proteins.
Used in Material Science:
N-(4'-methoxybenzenesulphonyl)-L-glutamic acid is used as a component in the development of novel materials such as hydrogels and polymers, where its unique structure and reactivity contribute to the creation of innovative and functional materials.

Upstream product

• 100-66-3 methoxybenzene 
• 142-47-2 monosodium L-glutamate 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 56-86-0 L-glutamic acid 

Downstream Products

• 1256268-92-4 methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate (S)-2-(4-methoxybenzenesulfonylamino)pentanedioic acid salt 
• 352655-42-6 N-(4'-methoxybenzenesulphonyl)-L-glutamic acid dichloride 
• 352655-43-7 (S)-N-(4'-methoxybenzenesulphonyl)-5-oxopyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis, biological evaluation, and enzyme assay of some 5-N-substituted-2-N-(arylsulphonyl)-L(+)glutamines as potential anticancer agents

Thirty 5-N-substituted-2-N-(arylsulphonyl)-L(+)glutamines were synthesized and evaluated biologically for their anticancer activities. The best active compound of this series showed 92.92% inhibition of tumor weight against Ehrlich Ascites Carcinoma cells. The most active compound was proved to be a competitive inhibitor of glutaminase in the enzyme assay. The best active compound may be a starting point to generate 'lead' for further exploration.

Possible anticancer agents: synthesis, pharmacological activity, and molecular modeling studies on some 5-N -Substituted-2-N-(substituted benzenesulphonyl)-L(+)Glutamines

On the basis of our earlier work, fortyone 5-N-substituted-2N-(substituted benzenesulphonyl)-L(+)glutamines were synthesized and screened for cancer cell inhibitory activity. The best active compounds showed 91% tumor cell inhibition, whereas other three compounds showed more than 80% inhibition. Two-dimensional quantitative structure–activity relationship modeling and three-dimensional quantitative structure–activity relationship k-nearest neighbor molecular field analysis studies were done to get an insight into structural requirements toward further improved anticancer activity. Considering the fact that these compounds are competitive inhibitors of glutaminase, a molecular docking study followed by molecular dynamic simulation analysis were performed. The work may help to develop new anticancer agents.

RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomaltriglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]-acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.

Possible antineoplastic agents, part 15: Synthesis, biological activity and quantitative structure activity relationship of substituted-2-(4′-methoxybenzenesulphonamido) glutaric acid analogs against Ehrlich ascites carcinoma

Some substituted-2-(4′-methoxybenzenesulphonamido) glutaric acid analogs (5a-m, 7a-d) have been synthesized and tested for their possible antineoplastic activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice using tumour (ascitic fluid) weight as activity parameter. Some of these compounds possess encouraging antitumour activity. A QSAR study, performed by the classical Hansch method, explains the significance of hydrophobic binding and electronic influence in the mechanism of antineoplastic action in this group of compounds.