99306-88-4

Basic information

• Product Name: (2S)-2-Benzylideneamino-3-phenylpropan-1-ol
• Synonyms: (2S)-2-Benzylideneamino-3-phenylpropan-1-ol
• CAS NO: 99306-88-4
• Molecular Weight: 239.317
• Mol File: 99306-88-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (2S)-2-Benzylideneamino-3-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-Benzylideneamino-3-phenylpropan-1-ol(99306-88-4)
• EPA Substance Registry System: (2S)-2-Benzylideneamino-3-phenylpropan-1-ol(99306-88-4)

Safety Data

• Hazardous Substances Data: 99306-88-4(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 100-52-7 benzaldehyde 
• 63-91-2 L-phenylalanine 

Downstream Products

• 129491-64-1 (2S,3S,4S,5S)-2,5-bis<<(tert-butyloxy)carbonyl>amino>-3,4-dihydroxy-1,6-diphenylhexane 
• 129491-63-0 (2S,3R,4R,5S)-2,5-bis[(1,1-dimethylethoxy)carbonyl]amino-1,6-diphenyl-3,4-dihydroxyhexane 
• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 158380-76-8 N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal 
• 158380-73-5 N-(tert-butoxycarbonyl)-N-benzyl-L-phenylalaninol 
• 168846-62-6 (2S,5S)-2,5-bis-<(1,1-dimethylethoxy)carbonylamino>-1,6-diphenylhex-3-ene 
• 168846-63-7 (2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene 
• 1004316-38-4 (3-benzenesulfonyl-1-benzyl-4-tert-butoxycarbonylamino-2-hydroxy-5-phenyl-pentyl)-benzyl-carbamic acid tert-butyl ester 
• 158554-91-7 (S)-3,4-dibenzylthiazolidine-2-thione 
• 225939-65-1 (S)-N-(1-Allyloxy-3-phenylprop-2-yl)-benzylamin 
• 225939-69-5 (S)-N-(1-Allyloxy-3-phenylprop-2-yl)-benzylidenamin-N-oxid 
• 717127-84-9 (S)-2-N-benzyl-((S)-2-N-benzyl-N-[(S)-2-N-benzyl-N-{(S)-2-N-allyl-N-benzylaminopropyl}amino-3-methylbutyl]amino-4-methyl-pentyl)amino-3-phenyl-propan-1-ol 
• 717127-90-7 (S)-2-N-benzyl-((S)-2-N-benzyl-N-[(S)-2-N-benzyl-N-{(S)-2-N-benzylaminopropyl}amino-3-methylbutyl]amino-4-methyl-pentyl)amino-3-phenyl-propan-1-ol 
• 725228-02-4 (S)-2-[benzyl-(2-hydroxyethyl)amino]-3-phenylpropan-1-ol 

Relevant articles and documents

SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors

Old World (Africa) and New World (South America) arenaviruses are associated with human hemorrhagic fevers. Efforts to develop small molecule therapeutics have yielded several chemical series including the 4-acyl-1,6-dialkylpiperazin-2-ones. Herein, we describe an extensive exploration of this chemotype. In initial Phase I studies, R1 and R4 scanning libraries were assayed to identify potent substituents against Old World (Lassa) virus. In subsequent Phase II studies, R6 substituents and iterative R1, R4 and R6 substituent combinations were evaluated to obtain compounds with improved Lassa and New World (Machupo, Junin, and Tacaribe) arenavirus inhibitory activity, in vitro human liver microsome metabolic stability and aqueous solubility.

Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol

N-alkyl 1,2-amino alcohols were rearranged stereospecifically by using TFAA/Et3N. This rearrangement has been used to synthesize N-isopropyl-3-(aryloxy)-2-hydroxypropylamines, β-adrenergic blocking agents such as (S)-toliprolol and (S)-propanolol.

N-Alkyl oxazolidines as stereocontrol elements in asymmetric Diels-Alder cycloadditions of 9-substituted anthracene derivatives

Chiral 9-oxazolidinyl anthracene derivatives have been prepared as single diastereoisomers by condensation of 9-anthraldehyde with the appropriate N-alkyl amino alcohol. Asymmetric Diels-Alder cycloadditions of these with N-methyl maleimide proceeds in go