99337-21-0

Upstream product

• 99337-14-1 2-phenyl-3-(trimethylsilyl)-(Z)-prop-2-enenitrile 
• 140-29-4 phenylacetonitrile 
• 2344-80-1 Chloromethyltrimethylsilane 
• 7677-24-9 trimethylsilyl cyanide 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 

Relevant academic research and scientific papers

Synthesis and fungicidal activities of silicon-containing derivatives of 2-aryl-3-(1H-1,2,4-triazol-1-yl)propanenitriles

A new series of silicon-containing derivatives of 2-aryl-3- (1H-1,2,4-triazol-1-yl)propanenitriles were synthesized and evaluated for fungicidal activities against rice sheath blight and powdery mildew on cucumber. These derivatives exhibited higher efficacy than reference fungicides.

Synthesis, spectral characterization, crystal structures and catalytic activity of a series of lanthanide(III) azepane dithiocarbamate complexes

A series of lanthanide(III) azepane dithiocarbamate (Aze-Dtc) complexes, [Ln(Aze-Dtc)3(Phen)] where Ln = La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Tb(III), Dy(III) and Er(III), have been synthesized under mild reaction conditions wi

Palladium- and Nickel-Catalyzed Reaction of Trimethylsilyl Cyanide with Acetylenes. Addition of Trimethylsilyl Cyanide to the Carbon-Carbon Triple Bonds

The reaction of trimethylsilyl cyanide (1) with acetylenes in the presence of a transition-metal complex was investigated.The structures of starting acetylenes and catalysts and both amounts of solvent and 1 highly affected product distributions.The PdCl2/pyridine catalyzed reaction of phenylacetylene and para-substituted phenylacetylenes with 1 resulted in the addition of 1 to the carbon-carbon triple bonds to give cyano-substituted vinylsilanes in good to high yields with high regio- and stereoselectivity.Ortho-substituted phenylacetylenes gave addition products less stereoselectively.Stereoselectivity affording Z adducts decreased in the order of para- meta- ortho-substituted phenylacetylenes.The NiCl2/DIBAH-catalyzed reaction of arylacetylenes was less stereoselective regardless of substitution patterns of arylacetylenes used.When the nickel-catalyzed reaction of arylacetylenes was run without solvent using an excess amount of 1, 5-amino-1H-pyrrole-2-carbonitriles were obtained as a single product, instead of the above simple addition products.The reaction of terminal aliphatic acetylenes with 1 also gave addition products with moderate stereoselectivity.Internal acetylenes gave complex mixtures including addition products and/or pyrrole derivatives.Diarylacetylenes afforded 5-amino-1H-pyrrole-2-carbonitriles selectively in the presence of a palladium or nickel catalyst (without solvent and an excess amount of 1).Intramolecular cyclization of a 1,6-diyne was also studied.

Palladium-catalysed Addition of trimethylsilyl Cyanide to Arylacetylenes

The reaction of arylacetylenes with trimethylsilyl cyanide (1) in the presence of a palladium complex resulted in addition of (1) across the carbon-carbon triple bond with high regio- and stereo-selectivity to give β-cyano-β-arylalkenylsilanes.