99359-28-1

Upstream product

• 3959-07-7 4-Bromobenzylamine 
• 106-95-6 allyl bromide 
• 107-05-1 3-chloroprop-1-ene 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 107-11-9 1-amino-2-propene 
• 27895-61-0 N-allyl-4-bromobenzaldimine 
• 1122-91-4 4-bromo-benzaldehyde 
• 246509-58-0 N-[(4-bromophenyl)methylidene]prop-2-en-1-amine 
• 497239-65-3 1-(4-bromobenzyl)-2-(bromomethyl)aziridine 

Downstream Products

• 55246-44-1 C₁₁H₁₁BrClNO 
• 1418218-11-7 N-allyl-N-(4-bromobenzyl)acrylamide 
• 1418218-43-5 1-(4-bromobenzyl)-1,5-dihydro-2H-pyrrol-2-one 
• 1453196-57-0 (S)-N²-benzyl-N¹-(4-bromobenzyl)-N²-hydroxypropane-1,2-diamine 
• 1453196-75-2 (S)-2-benzyl-5-(4-bromobenzyl)-3-methyl-1,2,5-oxadiazinan-6-one 
• 1415411-22-1 3-[1-(4-bromo-benzyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-propionic acid methyl ester 
• 798542-86-6 A₂₄₈ 
• 1383423-79-7 3-(4-bromobenzyl)-5-(iodomethyl)thiazolidine-2-thione 

Relevant academic research and scientific papers

IL4I1 INHIBITORS AND METHODS OF USE

Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

Synthesis of Cyclic N-Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)-Mediated Radical or Cationic Cyclizations of Unsaturated N-Alkoxyureas

In this study we describe the reactivity of unsaturated N-alkoxyureas in the presence of different combinations of a hypervalent iodine(III) reagent and a bromide source or TEMPO. Three complementary cyclizations can be achieved depending on the reaction conditions. On the one hand, PIFA with pyridinium bromide leads to an oxybromination reaction. On the other hand, bis(tert-butylcarbonyloxy)iodobenzene with tetrabutylammonium bromide or TEMPO triggers aminobromination or aminooxyamination reactions, respectively. Control experiments showed that the three reactions proceed through distinct mechanisms: the first process is ionic while the other two follow a radical manifold. (Figure presented.).

Photoinduced radical-initiated carboxylative cyclization of allyl amines with carbon dioxide

Visible light-promoted CO2 upgrading: a highly efficient and metal-free photochemical method for the carboxylative cyclization of allyl amines with CO2 is reported to prepare perfluoroalkylated oxazolidinones with high efficiency under ambient conditions by using perfluoroalkyl iodides as radical sources.

Rhodium-Catalyzed Regiodivergent Hydrothiolation of Allyl Amines and Imines

The regiodivergent Rh-catalyzed hydrothiolation of allyl amines and imines is presented. Bidentate phosphine ligands with larger natural bite angles (βn ≥ 99°), for example, DPEphos, dpph, or L1, promote a Markovnikov-selective hydrothiolation in up to 88% yield and >20:1 regioselectivity. Conversely, when smaller bite angle ligands (βn ≤ 86°), for example, dppbz or dppp, are employed, the anti-Markovnikov product is formed in up to 74% yield and >20:1 regioselectivity. Initial mechanistic investigations are performed and are consistent with an oxidative addition/olefin insertion/reductive elimination mechanism for each regioisomeric pathway. We hypothesize that the change in regioselectivity is an effect of diverging coordination spheres to favor either Rh-S or Rh-H insertion to form the branched or linear isomer, respectively.

Highly enantioselective intermolecular hydroamination of allylic amines with chiral aldehydes as tethering catalysts

Chirally LinkedIn: Chiral aldehydes are effective tethering catalysts for enantioselective intermolecular hydroamination, which provides access to vicinal diamine motifs in good yields and excellent enantioselectivities (see scheme). This work highlights simple chiral α-oxygenated aldehydes as effective organocatalysts capable of efficiently inducing asymmetry through transient intramolecularity. Copyright

Synthesis of nitrogen-containing heterocycles via ring-closing ene-ene and ene-yne metathesis reactions: An easy access to 1- and 2-benzazepine scaffolds and five- and six-membered lactams

Novel regioselective ring closing ene-yne metathesis provided an efficient access to different substituted 1-benzazepine scaffolds. The reported synthetic approach could also be used as a powerful tool for the selective formation of a highly functionaliza

A one-pot, three-component synthesis of thiazolidine-2-thiones

An efficient method for the synthesis of thiazolidine-2-thiones is described via regiospecific iodocyclization of an allyl amine, carbon disulfide, and iodine. Dehydrohalogenation of the iodo-derivatives gives thiazole-2(3H)-thiones. In addition, nucleoph

Electron transfer induced ring opening of 2-(bromomethyl)aziridines by magnesium in methanol

Magnesium metal in methanol was used as a simple electron transfer induced ring-opening reagent of 2-(bromomethyl)aziridines to afford allylamines derivatives in 70-90% yield.