99362-10-4

Usage

Uses

Used in Medicinal Chemistry:
N-(4-AMINO-BENZYL)-ACETAMIDE is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with diverse therapeutic applications. Its structural features facilitate chemical modifications, making it a versatile building block in medicinal chemistry.
Used in Drug Synthesis:
As an intermediate in drug synthesis, N-(4-AMINO-BENZYL)-ACETAMIDE plays a crucial role in the production of various medications. Its presence in the synthesis process can influence the pharmacokinetics and pharmacodynamics of the final drug product, potentially enhancing efficacy and safety profiles.
Used in Pharmaceutical Research:
N-(4-AMINO-BENZYL)-ACETAMIDE is employed in pharmaceutical research to explore its potential biological activity and therapeutic effects. Researchers investigate its interactions with biological targets to understand its mechanism of action and assess its suitability for treating specific medical conditions.
Used in Drug Development:
In the drug development industry, N-(4-AMINO-BENZYL)-ACETAMIDE serves as a valuable compound for the creation of novel therapeutic agents. Its potential pharmacological properties make it a promising candidate for further development into effective treatments for various diseases and disorders.
Used in Chemical Synthesis:
Beyond its applications in medicinal chemistry, N-(4-AMINO-BENZYL)-ACETAMIDE is also used in general chemical synthesis for the production of other organic compounds. Its reactivity and functional groups make it a useful component in a wide range of chemical reactions.

Upstream product

• 2735-73-1 1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one 
• 4403-71-8 (4-aminomethyl)aniline 
• 62133-07-7 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione 
• 588-46-5 N-(phenylmethyl)acetamide 
• 141-78-6 ethyl acetate 
• 56222-10-7 N-(4-nitrobenzyl)acetamide 
• 18600-42-5 4-nitrobenzylamine hydrochloride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 7409-30-5 p-nitrobenzylamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 32479-21-3 N-acetamid 
• 34185-04-1 N-(4-hydroxybenzyl)acetamide 
• 4403-71-8 (4-aminomethyl)aniline 
• 402508-93-4 tert-butyl (1R)-2-{4-[(acetylamino)methyl]anilino}-1-methylethyl-[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate 
• 32478-78-7 p-Tolylazobenzyliden-4-biphenylamin 
• 32478-80-1 N-p-Chlorphenylazobenzyliden-4-biphenylamin 
• 32478-92-5 N-p-Phenylazobenzylformamid 
• 32479-05-3 N-(p-Phenylazobenzyl)harnstoff 
• 32478-94-7 N-p-Phenylazobenzylcaprylamid 
• 32478-93-6 N-p-Phenylazobenzylbernsteinsaeuremonoamid 
• 887973-25-3 2-{[4-(aminomethyl)phenyl]amino}-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one 
• 1032638-76-8 C₂₀H₁₅Cl₂N₅O 
• 705256-52-6 ethyl N-{4-[(acetylamino)methyl]phenyl}glycinate 
• 32479-09-7 C₁₄H₁₃N₃O₂*C₁₃H₁₃N₃ 

Relevant academic research and scientific papers

NAMPT MODULATORS

Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

Lanthanum(III) triflate catalyzed direct amidation of esters

Lanthanum trifluoromethanesulfonate is an effective single-component catalyst for synthesizing a variety of amides directly from esters and amines under mild conditions. Highly selective amidation of esters and amines, as well as catalyst-controlled amidation of esters, demonstrated the effectiveness of the catalyst system.

NOVEL FLUORESCENT KINASE LIGANDS AND ASSAYS EMPLOYING THE SAME

The case relates to novel fluorescent kinase ligands, and to methods for using the fluorescent ligands, singly or in combination, in the identification of further ligands for kinases. The invention also relates to kits comprising the fluorescent kinase ligands.

8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS

This invention relates to 8-Heteroarylpurine Mnk2 Inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.

1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS

The invention provides compounds of the formula: (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a MAPKAP kinase: wherein A is a bond or a group CH2; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra -Rbwherein Ra is a bond, 0, CO, X1C(X2), C(X2)Xl, X1C(X2)X1, S, SO, S02, NRc, SO2NRc or NRcS02; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by 0, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4hydrocarbyl; and X1 is O, S or NRc and X2 is =O, =S or =NRc.

1,3-Dihydro-1,3-diacetyl-2H-benzimidazol-2-one: A new versatile and selective acetylating agent

1,3-Dihydro-1,3-diacetyl-2H-benzimidazol-2-one (4, DABI) was proven to be a versatile and selective acetylating agent for amines. Selectivity and reactivity are not only superior than those of other known acetylating agents, but also products could be easily separated with excellent yield.

Anti-Helicobacter pylori agents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives

In order to find a new class of anti-Helicobacter pylori (H. pylori) agents, a series of 4-[(3-acetamido)phenyl]-2-(substituted guanidino)thiazoles and some structurally rigid analoges were synthesized and evaluated for antimicrobial activity against H. pylori. Among the compounds obtained, high anti-H. pyrori activities were observed in benzyl derivative 34 (MIC = 0.025 μg/mL) and phenethyl derivatives 35 and 36 (MIC = 0.037 μg/mL and 0.017 μg/mL). Though alkyl derivatives generally showed lower activity, the 2-methoxyethyl derivative 28 preserved significant activity (MIC = 0.32 μg/mL) and also exhibited more potent gastric antisecretory activity than ranitidine. Structural restriction by bridging between the thiazole and the phenyl rings with an alkyl chain did not improve the activity in this series.

Nucleophilic Attack vs General Base Assisted Hydrolysis in the Reactions of Acetic Anhydride with Primary and Secondary Amines. pH-Yield Studies in the Recognition and Assessement of the Nucleophilic and General Base Reactions

The reaction of a set of primary and secondary amines with acetic anhydride in water at 25 deg C gave variable yields of the N-substituted acetamide in seven of the eight amines studied.The yield of the amide as a function of pH revealed the incursion in the most cases of a general base assisted hydrolysis of the acetic anhydride by the amine.From the pKa's of the amines and kw and kOH for acetic anhydride (the specific rates for the reaction of the anhydride with water and hydroxide, respectively), both kDN (for the formation of acetamides) and kGB (for the general base assisted hydrolysis) may be readily evaluated by fitting the pH-yield-data to pH-yield or pH-product ratio profiles.The reactions of ethyl chloroformate with aniline and benzylamine in water also showed the presence of the general base assisted reaction.It is concluded that (a) pH-yield data provide a new way of showing the existence of general base assisted hydrolysis in the presence of a direct nucleophilic displacement reaction, (b) the general base promoted reaction is sufficiently prevalent that it would be prudent to check specifically for its presence in any investigation of mechanisms of acyl transfer in water, and (c) until the extent of general base promoted hydrolysis can be predicted adequately, the possibility of such a reaction makes it difficult to predict yields of the products of the direct attack, and hence just how suitable a medium water may be for a particular preparative acyl transfer reaction.

pH optimization of nucleophilic reactions in water

We present a way of prescribing the pH for a reaction so as to obtain either (a) maximum yield in competition with hydrolysis or (b) selective reaction at either of two sites in such nucleophile-electrophile reactions as C-alkylation of acidic ketones and the acylation and sulfonylation of amines. First, we derive the following general equation for pHmax, the pH giving the highest yield of the product (P) of the reaction of a nucleophile (Nu) with a hydrolyzable electrophile (E) in water: pHmax = 1/2[log (kw/kOH) + PKw + pKw] (kw and kOH refer to the water- and hydroxide-promoted hydrolyses of E, Kw is the autoprotolysis constant of water, and Ka is the acid dissociation constant of NuH+, the conjugate acid of Nu). pHmax thus depends on a property of E (namely, kw/kOH) and a property of Nu (the pKa of NuH+), but not on the rate constant for the reaction of E with Nu or the concentration of Nu. We then deduce analogous approximate equations for maximum selectivity for reaction at either of two nucleophilic sites, specifically, equations giving pHxmax and pHymax, the pH values for the maximum yields of the respective products (Px and Py) of the reactions of E with the two nucleophiles. We find that (a) pH-yield profiles calculated from the equations concur with observed yields for reactions under pseudo-first-order conditions and (b) preparative experiments at the estimated pH values give good to excellent yields of clean products and high selectivity in both the C-alkylation and Schotten-Baumann reactions.