994-25-2

Upstream product

• 597-49-9 3-ethylpentan-3-ol 
• 816-79-5 3-ethyl-2-pentene 
• 35354-15-5 2,2-diethylbutanoyl chloride 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 96-22-0 pentan-3-one 
• 7446-70-0 aluminium trichloride 
• 71-43-2 benzene 

Downstream Products

• 816-79-5 3-ethyl-2-pentene 
• 4170-84-7 (1,1-diethyl-propyl)-benzene 
• 4468-40-0 (1-ethyl-1-methyl-butyl)-benzene 
• 5171-86-8 3,3,4,4-tetraethyl-hexane 
• 1067-08-9 3-ethyl-3-methyl-pentane 
• 69719-09-1 (1,1,2-trimethyl-butyl)-benzene 
• 92860-85-0 3-(1,1-Diethylpropyl)-cyclohex-4-en-1,2-dicarbonsaeure 

Relevant academic research and scientific papers

Direct halogenation of alcohols with halosilanes under catalyst- and organic solvent-free reaction conditions

A chemoselective method for the direct halogenation of different types of alcohols with halosilanes under catalyst- and solvent-free reaction conditions (SFRC) is reported. Various primary, secondary and tertiary benzyl alcohols and tertiary alkyl alcohols were directly transformed to the corresponding benzyl and alkyl halides, respectively, using chlorotrimethylsilane (TMSCl) and bromotrimethylsilane (TMSBr).

DECOMPOSITION DES ESTERS DE LA N-HYDROXYTHIOPYRIDONE-2. SYNTHESE DE QUELQUES NOUVEAUX HALOGENURES SECONDAIRES ET TERTIAIRES ENCOMBRES.

Hindered α,α-disubstituted and α,α,α-trisubstituted acyl chlorides give with N-hydroxy-2-thiopyridone, the corresponding esters.The decomposition of this compound in tetrachloromethane or in bromotrichloromethane as solvent and halogen atom source results in the formation of new very hindered secondary R1R2CHX (R1 = iPr or tBu; R2 = iPr or tBu; X = Cl or Br) and tertiary R1R2R3CX (R1 = R2 = R3 = iPr; R1 = tBu, R2 = iPr, R3 = Et or Me, X = Cl) alkyl halides.

Steroidal Silicon Side-Chain Analogues as Potential Antifertility Agents

A number of silicon-substituted analogues of ethynylestradiol that exhibit modified and enhanced biological activities have been synthesized.Particularly noteworthy are a group of estradiol analogues that exhibit high antifertility potency and markedly reduced estrogenic activity.The best compounds synthesized are 17α-estradiol (5) and 17α-estradiol (33), which show a separation of antifertility from estrogenic activity in the rat.The results of structure-activity studies indicate a good correlation between the observed biological activities and the calculated van der Waals volumes of the three variable silicon substituents.