99424-78-9Relevant academic research and scientific papers
Chemoselective zinc/HCl reduction of halogenated β-nitrostyrenes: Synthesis of halogenated dopamine analogues
Maresh, Justin J.,Ralko, Arthur A.,Speltz, Tom E.,Burke, James L.,Murphy, Casey M.,Gaskell, Zachary,Girel, Joann K.,Terranova, Erin,Richtscheidt, Conrad,Krzeszowiec, Mark
, p. 2891 - 2894 (2015/02/02)
A detailed account regarding the synthesis of 2- and 5-halogenated dopamine is given. The key step is a chemoselective reduction of a nitrostyrene by Zn/HCl at 0 °C. These conditions represent a simple, low-cost alternative to reduction by water-sensitive hydride donors and two-step procedures. Under these conditions, aryl fluoride, chloride, and bromide groups are stable. However, iodine undergoes significant reductive dehalogenation.
(DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES
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Page/Page column 135, (2009/10/09)
The invention relates to 5,6 - dihydropyrrolo [2,1-a] isoquinoline and pyrrolo[2,1-a] isoquinoline derivatives according to general formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.
2-FLUORO- AND 5-FLUORO-3,4-DIMETHYLPHENETHYLAMINE DERIVED FROM CLAISEN REARRANGEMENT PRODUCTS
Clark, Michael T.,Miller, Duane D.
, p. 4299 - 4300 (2007/10/02)
The Claisen rearrangement of 2-allyloxy-3-fluoroanisole followed by methylation provided the para-rearranged product along with the unexpected 3-(3,4-dimethoxy-2-fluorophenyl)-1-propene.
