99429-65-9Relevant academic research and scientific papers
4-Hydroxy-2-quinolones. 92. Reaction of 1-R-4-chloro-3-ethoxycarbonyl-2- oxo-1,2-dihydroquinolines with anilines
Ukrainets,Sidorenko,Gorokhova,Jaradat
, p. 343 - 351 (2006)
A preparative method is proposed and the synthesis of 4-arylamino-2-oxo-1, 2-dihydroquinolines has been effected. An X-ray structural investigation of 4-(4-chlorophenylamino)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxylic acid has been carried out enabl
4-Hydroxyquinol-2-ones. 85*. Synthesis of 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester
Ukrainets,Gorokhova,Sidorenko
, p. 1019 - 1021 (2007/10/03)
The behavior of 2-chloro-4-hydroxy- and 4-chloro-2-oxoquinoline-3- carboxylic acids under acid catalyzed esterification conditions with methanol has been studied. A method is proposed for obtaining 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester.
4-HYDROXY-2-QUINOLONES. 20. SYNTHESIS AND CHEMICAL CONVERSIONS OF ETHYL ESTERS OF CHLORO-SUBSTITUTED QUINOLINE-3-CARBOXYLIC ACIDS
Ukrainets, I. V.,Taran, S. G.,Gorokhova, O. V.,Marusenko, N. A.,Kovalenko, S. N.,et al.
, p. 167 - 175 (2007/10/03)
Preparative methods for the synthesis of ethyl esters of 2,4-dichloro- and 2-oxo-4-chloroquinoline-3-carboxylic acids were developed.The behavior of the compounds indicated was studied under conditions of alkaline and acidic hydrolysis, in reactions with some nucleophilic reagents, as well as in reductive dehalogenation.Results of the study of the antimicrobial and antiinflammatory activity of the synthesized compounds are presented.
