213181-22-7

Upstream product

• 213181-21-6 methyl 2,4-dichloroquinoline-3-carboxylate 
• 67-56-1 methanol 
• 99429-65-9 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 
• 134-20-3 2-carbomethoxyaniline 
• 118-48-9 isatoic anhydride 
• 108-59-8 malonic acid dimethyl ester 
• 6315-94-2 ethyl 2,4-dichloroquinoline-3-carboxylate 
• 73776-19-9 1H-4-hydroxy-2-oxoquinoline-3-carboxylic acid methyl ester 
• 40059-53-8 ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate 

Downstream Products

• 1092080-97-1 methyl 4-(4-methoxybenzylamino)-2-oxo-1,2-dihydroquinoline-3-carboxylate 

Relevant academic research and scientific papers

4-Hydroxyquinol-2-ones. 85*. Synthesis of 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester

The behavior of 2-chloro-4-hydroxy- and 4-chloro-2-oxoquinoline-3- carboxylic acids under acid catalyzed esterification conditions with methanol has been studied. A method is proposed for obtaining 2-chloro-4- hydroxyquinoline-3-carboxylic acid ethyl ester.

MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Ring Closure and Rearrangement Reactions of 4-Azido-2-oxoquinoline-3-carboxylates and 4-Azidocoumarin-3-carboxylates [1]

4-Azido-2-oxoquinoline-3-carboxylates and 4-azidocoumarin-3-carboxylates 6, which were obtained from the corresponding 4-hydroxy derivatives 1 via 4-tosylates 2 or 4-chloro compounds 4, cyclized upon thermolysis to 3-alkoxyisoxazolo[4,3-c]quinolin-4(5H)-ones or the corresponding coumarins 8, whereas at slightly higher temperatures a 3-O, 4-O-rearrangement took place to give the 4-alkoxy-isoxazolo[4,3-c]-quinolin-3-ones and the corresponding coumarins 9. The necessary reaction conditions could be obtained easily with the help of differential scanning calorimetry.