99500-87-5Relevant academic research and scientific papers
AZAINDOLE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING THE SAME
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Paragraph 0168; 0225; 0226, (2015/02/18)
The invention provides compounds of formula (I) and methods of treating a Mycobacterium infection or tuberculosis, or inhibiting DprE1 with the same.
Selective reduction of ketones using water as a hydrogen source under high hydrostatic pressure
Tomin, Anna,Lazarev, Alexander,Bere, Matthew P.,Redjeb, Hana,T?r?k, Béla
experimental part, p. 7321 - 7326 (2012/09/22)
A selective reduction of a broad variety of ketones is described. The method is based on the combination of a Ni-Al alloy and high hydrostatic pressure (HHP, 2.8 kbar) in an aqueous medium. The reaction of the Ni-Al alloy with water provides in situ hydrogen generation and the high pressure ensures that the H2 formed remains in the solution, thus the CO reduction readily occurs. The application of the HHP resulted in selective formation of the desired products and the common problem of non-selective overhydrogenation could be avoided. In most cases the reductions resulted in high yields and excellent selectivities without the use of any base.
NBu4NI-catalyzed direct synthesis of α-ketoamides from aryl methyl ketones with dialkylformamides in water using TBHP as oxidant
Mai, Wen-Peng,Wang, Hui-Hui,Li, Zhi-Cheng,Yuan, Jin-Wei,Xiao, Yong-Mei,Yang, Liang-Ru,Mao, Pu,Qu, Ling-Bo
supporting information, p. 10117 - 10119 (2012/10/30)
A novel and easy practical direct synthesis of α-ketoamides has been developed without metals in water. This procedure was catalyzed by nBu 4NI using TBHP as oxidant from simple substrates, aryl methyl ketones and dialkylformamides. The Royal Society of Chemistry 2012.
Two-component supramolecular helical architectures: Creation of tunable dissymmetric cavities for the inclusion and chiral recognition of the third components
Kodama, Koichi,Kobayashi, Yuka,Saigo, Kazuhiko
, p. 2144 - 2152 (2008/02/04)
The inclusion and chiral recognition of racemic arylalkanols by supramolecular helical architectures consisting of enantiopure primary amines and achiral carboxylic acids were thoroughly studied. Among the architectures examined, a supramolecular helical architecture composed of the salt of enantiopure erythro-2-amino-1.2-diphenylethanol (1b) and benzoic acid (2a) was found to include a wide variety of racemic arylalkanols with recognition of their chirality. The helical architecture gave a dissymmetric 1D groove in the salt crystal, and the arylalkanols were enantioselectively included in the groove. The size and shape of the groove were tunable by proper selection of the achiral carboxylic acid component. The origin of the chiral recognition with the combination 1b/2a is discussed on the basis of X-ray crystallographic analyses.
Dimethylbenzene derivatives
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, (2008/06/13)
Compounds of the formula (I): wherein X is a —(C═CH2)— group or a —CH(CH3)— group, with the proviso that when X is a —(C═CH2)— group, R1 is a C1-10 alkyl group or a C2-10 alkenyl group and
