99508-26-6

Usage

Uses

Used in Organic Synthesis:
(4-(azidomethyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone is used as a precursor in the synthesis of various organic compounds, leveraging its highly reactive nature and unique structural features.
Used in Drug Discovery:
(4-(azidomethyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone is used as a starting material in drug discovery, where its structural features and reactivity can be exploited to develop potential pharmaceuticals or agrochemicals.
Used in Research and Development:
(4-(azidomethyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone is utilized in research and development for the exploration of its potential applications in various fields, including the synthesis of new compounds and the advancement of existing technologies.
Used in Chemical Storage and Handling:
Due to its potentially hazardous properties, (4-(azidomethyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone is also used as a subject for the development of safe storage and handling protocols to ensure the safety of researchers and the environment.

Upstream product

• 60211-57-6 3,5-dichlorobenzyl alcohol 
• 99508-25-5 (4-chlorophenyl)(2,6-dichloro-4-(hydroxymethyl)phenyl)methanone 
• 99508-22-2 2,6-dichloro-4-methylbenzoyl chloride 
• 99520-05-5 2,6-dichloro-4-methylbenzoic acid 
• 25186-47-4 3,5-dichlorotoluene 
• 99508-24-4 (4-(bromomethyl)-2,6-dichlorophenyl)(4'-chlorophenyl)methanone 
• 99520-09-9 (4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone 
• 99508-23-3 2',6',4''-trichloro-4'-methylbenzophenone 

Downstream Products

• 99519-84-3 carboxyamidotriazole 
• 187739-60-2 5-amino-1-(4-[4-chlorobenzoyl]-3,5-dichlorobenzyl)-1,2,3-triazole-4 carboxamide orotate 

Relevant academic research and scientific papers

Method for synthesizing carboxamide triazole

The invention relates to a method for synthesizing carboxamide triazole. The method for synthesizing carboxamide triazole comprises the following steps: (1) sequentially carrying out halogenation reaction and azide substitution reaction by adopting a one-

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex i

Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac function. An analysis of the effects of mubritinib on cardiac cells showed that this drug did not inhibit HER2 as reported, but directly inhibits mitochondrial respiratory complex I, reducing cardiac-cell beat rate, with prolonged exposure resulting in cell death. We used a library of chemical variants of mubritinib and showed that modifying the 1H-1,2,3-triazole altered complex I inhibition, identifying the heterocyclic 1,3-nitrogen motif as the toxicophore. The same toxicophore is present in a second anti-cancer therapeutic carboxyamidotriazole (CAI) and we demonstrate that CAI also functions through complex I inhibition, mediated by the toxicophore. Complex I inhibition is directly linked to anti-cancer cell activity, with toxicophore modification ablating the desired effects of these compounds on cancer cell proliferation and apoptosis.

Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazoles orotate formulations

New polymorphs of 5-amino or substituted amino 1,2,3-triazole and substituted derivatives thereof, of orotates of the carboxyamidotriazoles, of formulations of the triazoles and orotic acid in the ratio of 1:1 to 1:4 (base:acid) and of safer processes of

NOVEL COMPOSITIONS AND PROCESSES FOR PREPARING 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES AND TRIAZOLE OROTATE FORMULATIONS

New polymorphs of 5-amino or substituted amino 1, 2, 3-triazole and substituted derivatives thereof, of orotates of the carboxyamidotriazoles, of formulations of the triazoles and orotic acid in the ratio of 1:1 to 1:4 (base:acid) and of safer processes o

Benzylated 1,2,3-triazoles as anticoccidiostats

Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-1,2,3-triazoles 3. In Scheme II, the benzyl halides 5 were employed to alkylate the sodium salt of 5-amino-4-carbamoyl-1,2,3-triazole (7). Preliminary screening data against Eimeria acervulina and E. tenella in chickens suggested structural requirements for maximizing activity. Further evaluation against a relatively resistant series of eight Eimeria field isolates revealed L-651,582 (3a) to be a highly effective coccidiostat. However, unacceptable tissue residues precluded further development. Mechanistic studies on this series of 5-amino-4-carbamoyl-1,2,3-triazoles and, in particular, on L-651,582 (3a) revealed that its mode of action does not involve inhibition of IMP dehydrogenase, but probably interferes with host cell calcium entry. In addition, L-651,582 has been found to have antiproliferative activity in several disease models and was recently reported to possess antimetastatic activity in a model of ovarian cancer progression.

5-amino or substituted amino 1,2,3-triazoles

Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with a