99508-25-5

Usage

Uses

Used in Pharmaceutical Industry:
(4-chlorophenyl)(2,6-dichloro-4-(hydroxymethyl)phenyl)methanone is used as an intermediate in the production of various pharmaceuticals. Its unique chemical structure allows it to serve as a building block for the development of new drugs, contributing to the advancement of medical treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, (4-chlorophenyl)(2,6-dichloro-4-(hydroxymethyl)phenyl)methanone is utilized as a key component in the synthesis of pesticides and other agricultural chemicals. Its role in this industry is essential for the development of effective solutions to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
(4-chlorophenyl)(2,6-dichloro-4-(hydroxymethyl)phenyl)methanone is also employed in the synthesis of other organic compounds, showcasing its versatility in chemical reactions. Its presence in various organic synthesis processes highlights its importance in the creation of a wide range of chemical products, from specialty chemicals to advanced materials.

Upstream product

• 2905-62-6 3,5-dichlorobenzoyl chloride 
• 51-36-5 3,5-dichlorobenzoic acid 
• 99520-09-9 (4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone 
• 122-01-0 4-chloro-benzoyl chloride 
• 616195-94-9 3,5-dichloro(triisopropylsilyloxymethyl)benzene 
• 60211-57-6 3,5-dichlorobenzyl alcohol 

Downstream Products

• 187739-60-2 5-amino-1-(4-[4-chlorobenzoyl]-3,5-dichlorobenzyl)-1,2,3-triazole-4 carboxamide orotate 
• 99519-84-3 carboxyamidotriazole 
• 99508-26-6 (4-(azidomethyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone 
• 99508-24-4 (4-(bromomethyl)-2,6-dichlorophenyl)(4'-chlorophenyl)methanone 

Relevant academic research and scientific papers

Preparation method of 3, 5-dichlorobenzaldehyde and carboxamide triazole intermediate

The invention relates to a preparation method of 3, 5-dichlorobenzene methanol and a carboxylamine triazole intermediate. The preparation method of the 3, 5-dichlorobenzene methanol comprises the following steps: mixing the 3, 5-dichlorobenzene methanol with potassium borohydride and zinc chloride in a solvent, heating to reflux, and carrying out reduction reaction; after the reduction reaction isfinished, concentrating to prepare a crude product; and adding a hydrochloric acid aqueous solution and toluene into the crude product for extraction or adding toluene for extraction, collecting a toluene phase, washing the toluene phase with an alkaline aqueous solution and water to be neutral, then concentrating the toluene phase to be dry, and recrystallizing the obtained solid with n-hexane.According to the synthetic method of 3, 5-dichlorobenzene methanol, the raw materials are easy to obtain, the reaction conditions are mild and easy to control, the product is easy to purify, and the yield of the product is high.

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex i

Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac function. An analysis of the effects of mubritinib on cardiac cells showed that this drug did not inhibit HER2 as reported, but directly inhibits mitochondrial respiratory complex I, reducing cardiac-cell beat rate, with prolonged exposure resulting in cell death. We used a library of chemical variants of mubritinib and showed that modifying the 1H-1,2,3-triazole altered complex I inhibition, identifying the heterocyclic 1,3-nitrogen motif as the toxicophore. The same toxicophore is present in a second anti-cancer therapeutic carboxyamidotriazole (CAI) and we demonstrate that CAI also functions through complex I inhibition, mediated by the toxicophore. Complex I inhibition is directly linked to anti-cancer cell activity, with toxicophore modification ablating the desired effects of these compounds on cancer cell proliferation and apoptosis.

Preparation of Solid Polyfunctional Alkynylzinc Pivalates with Enhanced Air and Moisture Stability for Organic Synthesis

We report the preparation of solid and air-stable polyfunctionalized alkynylzinc pivalates from the corresponding alkynes using TMPZnOPiv (TMP=2,2,6,6-tetramethylpiperidyl) as base. These organozinc pivalates are obtained as powders under mild conditions

Novel compositions and processes for preparing 5-amino or substituted amino 1,2,3-triazoles and triazoles orotate formulations

New polymorphs of 5-amino or substituted amino 1,2,3-triazole and substituted derivatives thereof, of orotates of the carboxyamidotriazoles, of formulations of the triazoles and orotic acid in the ratio of 1:1 to 1:4 (base:acid) and of safer processes of

NOVEL COMPOSITIONS AND PROCESSES FOR PREPARING 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES AND TRIAZOLE OROTATE FORMULATIONS

New polymorphs of 5-amino or substituted amino 1, 2, 3-triazole and substituted derivatives thereof, of orotates of the carboxyamidotriazoles, of formulations of the triazoles and orotic acid in the ratio of 1:1 to 1:4 (base:acid) and of safer processes o