99512-42-2

Upstream product

• 186581-53-3 diazomethane 
• 6049-47-4 5-oxo-3-phenylhexanoic acid 
• 52129-50-7 methyl 3-phenylhex-5-enoate 
• 103-26-4 Methyl cinnamate 
• 67-64-1 acetone 
• 18365-23-6 methyl 2-(tributylstannyl)acetate 
• 1896-62-4 (E)-benzalacetone 
• 118527-80-3 (4R,6S)-4-Phenyl-6-trimethylsilanyl-oxepan-2-one 
• 493-72-1 5-phenyl-cyclohexane-1,3-dione 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 1261085-79-3 5-benzoyl-6-methyl-4-phenyl-3,4-dihydro-2H-pyran-2-one 
• 104-55-2 3-phenyl-propenal 
• 1261085-76-0 5-acetyl-6-methyl-4-phenyl-3,4-dihydro-2H-pyran-2-one 

Downstream Products

• 1008-73-7 4-phenyldihydrofuran-2(3H)-one 
• 344596-97-0 5,5-Dimethoxy-3-phenyl-hexanoic acid methyl ester 

Relevant academic research and scientific papers

DBU-Catalyzed Ring-Opening and Retro-Claisen Fragmentation of Dihydropyranones

We present a general protocol for the formal Michael addition of acetone to α,β-unsaturated esters and amides, a transformation difficult to perform using current methods. The protocol comprises of an amidine catalyzed relay ring-opening and fragmentation

Direct benzylation and allylic alkylation in high-temperature water without added catalysts

In high-temperature water a series of benzyl and allylic alcohols reacted with 1,3-dicarbonyl compounds and activated aromatic compounds to give the alkylated products without added catalysts.

Highly regioselective addition of an ester enolate equivalent to α,β-unsaturated ketones: Selective formation of both isomers derived from 1,2- and 1,4-additions using α-stannyl ester with additives

The reaction of α-stannyl ester with α,β-unsaturated ketones in the presence of stannous chloride (SnCl2) and chlorosilanes (Me3SiCl or Me2SiCl2) gave 1,2- and 1,4-addition products, respectively.

USE OF 1,3-DIOXIN-4-ONES AND THEIR RELATED COMPOUNDS IN SYNTHESIS. 27. NOVEL ASYMMETRIC HETERO-DIELS-ALDER REACTION USING CHIRAL SPIRO 5-METHYLENE-1,3-DIOXANE-4,6-DIONES HAVING 1-MENTHONE AT THE 2-POSITION

Diastereofacially selective hetero-Diels-Alder reaction of spiro (E or Z)-5-arylidene-1,3-dioxane-4,6-diones and 2-methoxypropene was studied.The dihydropyrans thus obtained were converted to optically active β-arylated δ-oxohexanoic acids.The diastereofa

3-Substituted-γ-butyrolactones from 5-Trimethylsilyl-2-cyclohexenone. Synthesis of (-)-Enterolactone

1,4-Adducts of 5-trimethylsilyl-2-cyclohexenone (1) with Grignard reagents were converted to various hexanoate derivatives and γ-butyrolactones.Starting from optically pure 1, (-)-enterolactone (Factor X) was synthesized.

Enol Lactone Inhibitors of Serine Proteases. The Effect of Regiochemistry on the Inactivation Behavior of Phenyl-Substituted (Halomethylene)tetra- and -dihydrofuranones and (Halomethylene)tetrahydropyranones toward α-Chymotrypsin: Stable Acyl Enzyme Inter

We have found that α-aryl-substituted halo enol lactones (I and II) are effective mechanism-based inactivators for chymotrypsin.In this study, we have investigated, for comparative purposes, halo enol lactones with aryl functions situated β and γ to the l

ASYMMETRIC SYNTHESIS OF β-SUBSTITUTED δ-KETOESTERS VIA MICHAEL-ADDITIONS OF SAMP/RAMP-HYDRAZONES TO α,β-UNSATURATED ESTERS, VIRTUALLY COMPLETE 1.6-ASYMMETRIC INDUCTION

A simple and efficient 3-step asymmetric synthesis of β-substituted δ-ketoesters 3 in 45-62percent overall chemical yield and >=96-ca.100percent ee is described.The key step is an asymmetric Michael-addition of lithiated methylketone-SAMP- or RAMP-hydrazones to α,β-unsaturated esters 2 with virtually complete 1.6-asymmetric induction.