99532-53-3

Basic information

• Product Name: 5-fluoro-3-acetylindole
• Synonyms: 5-fluoro-3-acetylindole;1-(5-fluoro-1H-indol-3-yl)ethanone
• CAS NO: 99532-53-3
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177
• Mol File: 99532-53-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-fluoro-3-acetylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-3-acetylindole(99532-53-3)
• EPA Substance Registry System: 5-fluoro-3-acetylindole(99532-53-3)

Safety Data

• Hazardous Substances Data: 99532-53-3(Hazardous Substances Data)

Upstream product

• 399-52-0 5-fluoro-1H-indole 
• 108-24-7 acetic anhydride 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 371-40-4 4-fluoroaniline 
• 75-36-5 acetyl chloride 
• 127-19-5 N,N-dimethyl acetamide 
• 348-36-7 ethyl 5-fluoro-1H-indole-2-carboxylate 
• 399-76-8 5-fluoroindole-2-carboxylic acid 
• 99532-44-2 1-(benzenesulfonyl)-5-fluoro-1H-indole 

Downstream Products

• 1594965-96-4 4-[1-(4-phenylbenzyl)-5-fluoro-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid 
• 1594966-00-3 4-{1-[4-(trifluoromethyl)benzyl]-5-fluoro-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoic acid 
• 1594966-01-4 4-[1-(4-tert-butylbenzyl)-5-fluoro-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid 
• 1594966-03-6 4-{1-[2,4-bis(trifluoromethyl)benzyl]-5-fluoro-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoic acid 
• 1594966-07-0 4-[1-(3,5-dimethylbenzyl)-5-fluoro-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid 
• 1594966-08-1 4-[1-(2,4,6-trimethylbenzyl)-5-fluoro-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid 
• 1594966-36-5 C₂₆H₁₈FNO₄ 
• 1594966-40-1 C₂₁H₁₃F₄NO₄ 
• 1594966-42-3 C₂₄H₂₂FNO₄ 
• 1594966-43-4 C₂₂H₁₂F₇NO₄ 
• 1594966-46-7 C₂₂H₁₈FNO₄ 
• 1594966-49-0 C₂₃H₂₀FNO₄ 
• 1594965-59-9 ethyl 4-[1-(4-phenylbenzyl)-5-fluoro-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate 
• 1594965-60-2 ethyl 4-{1-[4-(trifluoromethyl)benzyl]-5-fluoro-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoate 

Relevant articles and documents

Natural product Pimprinine derivative as well as preparation method and application thereof

The invention discloses a Pimprinine derivative as shown in a formula III in the description. The invention also discloses a preparation method of the Pimprinine derivative, and a series of Pimprinine derivatives are synthesized by taking Pimprinine as a lead, combining the structural characteristics of Pimprinine, taking cheap and easily available indole as a raw material, modifying and transforming different sites of a framework structure of the indole and introducing different substituent groups. The Pimprinine derivative disclosed by the invention has good bactericidal activity, shows efficient and/or broad-spectrum bactericidal activity, and can be applied to crop diseases caused by fungi, bacteria and viruses.

Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C?H Activation

An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biological properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C?H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Additionally, a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction.

SMAC MIMETICS USED AS IAP INHIBITORS AND USE THEREOF

Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particu