636-80-6

Basic information

• Product Name: PICOLINIC ACID HYDROCHLORIDE
• Synonyms: PICOLINIC ACID HYDROCHLORIDE;PYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE;2-pyridinecarboxylicacid,hydrochloride;2-PICOLINIC ACID HCL;2-PICOLINIC ACID HYDROCHLORIDE;ALPHA-PICOLINIC ACID HCL;PicolinicacidHCl
• CAS NO: 636-80-6
• Molecular Formula: C₆H₆NO₂*Cl
• Molecular Weight: 159.57
• EINECS: 211-266-4
• Product Categories: Pyridinium Compounds
• Mol File: 636-80-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 229 °C(Solv: ethanol (64-17-5))
• Boiling Point: 292.5 °C at 760 mmHg
• Flash Point: 130.7 °C
• Appearance: /
• Vapor Pressure: 0.000836mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: PICOLINIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PICOLINIC ACID HYDROCHLORIDE(636-80-6)
• EPA Substance Registry System: PICOLINIC ACID HYDROCHLORIDE(636-80-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 636-80-6(Hazardous Substances Data)

Usage

General Description

Picolinic acid hydrochloride is a synthetic derivative of pyridine and is commonly used as a chelating agent in metal ion coordination complexes. It has the chemical formula C6H6N2O2·HCl and is often used in the synthesis of various pharmaceuticals and as a reagent in organic chemistry. Picolinic acid hydrochloride is also used as a dietary supplement and has been studied for its potential therapeutic effects in treating conditions such as diabetes, Alzheimer's disease, and schizophrenia. It is a white crystalline powder that is soluble in water and has a bitter taste. Additionally, it is considered to be safe for consumption at recommended dosages, however, like any chemical, it should be handled and stored with proper care.

InChI:InChI=1/C6H5NO2.ClH/c8-6(9)5-3-1-2-4-7-5;/h1-4H,(H,8,9);1H

Upstream product

• 98-98-6 2-Picolinic acid 
• 1121-60-4 pyridine-2-carbaldehyde 
• 67-56-1 methanol 

Downstream Products

• 5470-22-4 4-chloropicolinic acid 
• 2524-52-9 ethyl-2-picolinate 
• 88912-25-8 4,6-dichloro-2-pyridinecarboxylic acid 
• 496849-77-5 4,5,6-trichloropicolinic acid 
• 4043-87-2 pipecolic Acid 
• 5340-88-5 butyl pyridine-2-carboxylate 
• 5394-95-6 Picolinsaeure-hexylester 
• 83417-23-6 5-(pyridin-2-yl)-1H-1,2,4-triazol-3-amine 
• 15883-20-2 2',6'-pipecoloxylidide 
• 78289-28-8 pipecolic-2-acid-2',6'-xylidide 
• 39627-98-0 2-pyridine-carboxamide-N-(2,6-dimethylphenyl) 
• 99586-65-9 4-chloropicolinamide 
• 29745-44-6 pyridine-2-carbonyl chloride 
• 144710-94-1 chromium(III) picolinate hydrate 

Relevant articles and documents

Crystal growth, spectral, optical and thermal properties of semiorganic nonlinear optical material: Picolinic acid hydrochloride

The bulk single crystal of 2-picolinic acid hydrochloride (PHCL) (a semi-organic nonlinear optical material of dimensions 25 × 15 × 10 mm3) was successfully grown by slow solvent evaporation technique. The XRD results revealed the cell parameters and the centrosymmetric nature of the crystal structure. FT-IR spectral study identified the functional groups, nature of bonding and their bond strength. The UV-Vis-NIR studies recognized the optical transmittance window and the lower cut off wavelength of the PHCL crystal and thus it could be performed as a NLO material. 1H NMR and 13CNMR spectra were correlated with the XRD standard for the molecular structure reveals harmony of the materials. Thermal properties of the crystal were studied by thermo gravimetric analysis (TGA) and differential thermal analysis (DTA); the derived kinetic parameter values support the intuitive association of picolinicacid and HCl leads to the spontaneous formation of PHCL with a first order reaction. The presence of a proton and a proton acceptor groups provide the necessary stability to induce charge asymmetry in the PHCL structure. The load dependent hardness values of the crystal were measured by microhardness testing.

Method for preparing methyl 4-chloropicolinate

The invention discloses a method for preparing methyl 4-chloropicolinate. The method comprises the following steps: step 1, in the presence of a catalyst, enabling chlorination between a methyl pyridine-2-carboxylate hydrochloride and 2-picolinic acid hydrochloride mixture and sulfoxide chloride; step 2, after chlorination is finished, enabling reaction between the mixture and methanol to generate methyl 4-chloropicolinate. Methyl 4-chloropicolinate prepared by the method is higher in purity, and the melting point of N-methyl-4-chloropyridine-2-carboxamide synthesized by methyl 4-chloropicolinate prepared by the method can be up to 55 DEG C, and sorafenib prepared by follow-up reactions is changed from faint yellow to white, has the liquid-phase purity of 99.9 percent or above, so that the product quality is remarkably improved.

Benzothiadiazine compounds

Compound of formula (I): wherein: R1 represents hydroxy, RCO—O— or RCO—NRa—, R2 represents hydrogen, halogen, or hydroxy, R′CO—O or R′CO—NR′a—, R and R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, Ra and R′a, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)acyl, aryl or heteroaryl, its isomer and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as AMPA modulators.