636-80-6

Usage

Uses

Used in Pharmaceutical Synthesis:
Picolinic acid hydrochloride is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Organic Chemistry:
As a reagent in organic chemistry, picolinic acid hydrochloride is employed in various chemical reactions, facilitating the synthesis of complex organic compounds and aiding in research and development.
Used as a Dietary Supplement:
Picolinic acid hydrochloride is used as a dietary supplement, providing potential health benefits and supporting the treatment of certain conditions.
Used in Therapeutic Research:
Picolinic acid hydrochloride is used as a subject of research for its potential therapeutic effects in treating conditions such as diabetes, Alzheimer's disease, and schizophrenia, offering new avenues for medical treatment and intervention.
Used in Metal Ion Coordination Complexes:
As a chelating agent, picolinic acid hydrochloride is used in the formation of metal ion coordination complexes, playing a crucial role in various chemical and industrial processes.

InChI:InChI=1/C6H5NO2.ClH/c8-6(9)5-3-1-2-4-7-5;/h1-4H,(H,8,9);1H

Upstream product

• 98-98-6 2-Picolinic acid 
• 67-56-1 methanol 
• 1121-60-4 pyridine-2-carbaldehyde 

Downstream Products

• 5335-69-3 octyl 2-pyridinecarboxylate 
• 5470-22-4 4-chloropicolinic acid 
• 2524-52-9 ethyl-2-picolinate 
• 88912-25-8 4,6-dichloro-2-pyridinecarboxylic acid 
• 496849-77-5 4,5,6-trichloropicolinic acid 
• 4043-87-2 pipecolic Acid 
• 5340-88-5 butyl pyridine-2-carboxylate 
• 5394-95-6 Picolinsaeure-hexylester 
• 73455-13-7 4,5-dichloro-pyridine-2-carboxylic acid 
• 3105-95-1 pipecolinic acid 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 19798-80-2 2-Amino-4-chloropyridine 
• 144710-94-1 chromium(III) picolinate hydrate 
• 39627-98-0 2-pyridine-carboxamide-N-(2,6-dimethylphenyl) 

Relevant academic research and scientific papers

Crystal growth, spectral, optical and thermal properties of semiorganic nonlinear optical material: Picolinic acid hydrochloride

The bulk single crystal of 2-picolinic acid hydrochloride (PHCL) (a semi-organic nonlinear optical material of dimensions 25 × 15 × 10 mm3) was successfully grown by slow solvent evaporation technique. The XRD results revealed the cell parameters and the centrosymmetric nature of the crystal structure. FT-IR spectral study identified the functional groups, nature of bonding and their bond strength. The UV-Vis-NIR studies recognized the optical transmittance window and the lower cut off wavelength of the PHCL crystal and thus it could be performed as a NLO material. 1H NMR and 13CNMR spectra were correlated with the XRD standard for the molecular structure reveals harmony of the materials. Thermal properties of the crystal were studied by thermo gravimetric analysis (TGA) and differential thermal analysis (DTA); the derived kinetic parameter values support the intuitive association of picolinicacid and HCl leads to the spontaneous formation of PHCL with a first order reaction. The presence of a proton and a proton acceptor groups provide the necessary stability to induce charge asymmetry in the PHCL structure. The load dependent hardness values of the crystal were measured by microhardness testing.

2-Carboxypyridinium Chloride Monohydrate

The structure of the monohydrated polymorph of picolinic acid hydrochloride, C6H6NO2+*Cl-*H2O, has been determined and the role of the lattice water in the hydrogen bonding to the chloride ion considered.In the anhydrous complex of the same compound, an interaction between the chloride and the pyridinium proton is found .In addition, the water of hydration forms bridging links between chloride ions and with a carboxylic acid H atom .An itramolecular hydrogen bond between the carboxyl O atom and the H atom of the pyridinium moiety is also found .

Method for preparing methyl 4-chloropicolinate

The invention discloses a method for preparing methyl 4-chloropicolinate. The method comprises the following steps: step 1, in the presence of a catalyst, enabling chlorination between a methyl pyridine-2-carboxylate hydrochloride and 2-picolinic acid hydrochloride mixture and sulfoxide chloride; step 2, after chlorination is finished, enabling reaction between the mixture and methanol to generate methyl 4-chloropicolinate. Methyl 4-chloropicolinate prepared by the method is higher in purity, and the melting point of N-methyl-4-chloropyridine-2-carboxamide synthesized by methyl 4-chloropicolinate prepared by the method can be up to 55 DEG C, and sorafenib prepared by follow-up reactions is changed from faint yellow to white, has the liquid-phase purity of 99.9 percent or above, so that the product quality is remarkably improved.

KetoABNO/NOx Cocatalytic Aerobic Oxidation of Aldehydes to Carboxylic Acids and Access to α-Chiral Carboxylic Acids via Sequential Asymmetric Hydroformylation/Oxidation

A method for aerobic oxidation of aldehydes to carboxylic acids has been developed using organic nitroxyl and NOx cocatalysts. KetoABNO (9-azabicyclo[3.3.1]nonan-3-one N-oxyl) and NaNO2 were identified as the optimal nitroxyl and NOx sources, respectively. The mildness of the reaction conditions enables sequential asymmetric hydroformylation of alkenes/aerobic aldehyde oxidation to access α-chiral carboxylic acids without racemization. The scope, utility, and limitations of the oxidation method are further evaluated with a series of achiral aldehydes bearing diverse functional groups.

Benzothiadiazine compounds

Compound of formula (I): wherein: R1 represents hydroxy, RCO—O— or RCO—NRa—, R2 represents hydrogen, halogen, or hydroxy, R′CO—O or R′CO—NR′a—, R and R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, Ra and R′a, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)acyl, aryl or heteroaryl, its isomer and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as AMPA modulators.