99909-62-3 Usage
General Description
5-ISOPROPYL-3-(METHOXYCARBONYL)-2H-CYCLOHEPTA[B]FURAN-2-ONE is a chemical compound with a molecular formula of C13H16O3. It is a furanone derivative with a cyclohepta[b]furan-2-one core structure. This chemical is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological and pharmacological activities, particularly in the fields of antimicrobial and antitumor properties. Its unique structure and properties make it a valuable building block for the preparation of diverse organic compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 99909-62-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,9,0 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 99909-62:
(7*9)+(6*9)+(5*9)+(4*0)+(3*9)+(2*6)+(1*2)=203
203 % 10 = 3
So 99909-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H14O4/c1-8(2)9-5-4-6-11-10(7-9)12(13(15)17-3)14(16)18-11/h4-8H,1-3H3
99909-62-3Relevant articles and documents
Synthesis and analysis of positive inotropic effects of 3-substituted-2H-cyclohepta[b]furan-2-one derivatives
Yokota,Yanagisawa,Kosakai,Wakabayashi,Tomiyama,Yasunami
, p. 865 - 871 (2007/10/02)
Several 3-substituted-2H-cyclohepta[h]furan-2-one derivatives were prepared and tested in vitro for positive inotropic character. Introduction of an isopropyl group at the 5-position of compound 8a caused an increase of PIC50 (negative logarithm of the dosage which increases the contractile force by 50%) from 4.48 to 5.10. Among the 5-isopropyl-8-alkoxy compounds, the isopropoxy compound 12f had the most potent activity with a PIC50 value of 5.99. Conversion of the ester group at the 3-position to a methylene group and of the alkoxy group at the 8-position to a substituted amino group caused a decrease in activity. The most active compound, 12f, was also found to bave a weaker heart rate (HR)-increasing effect compared to milrinone and amrinone.
