99973-53-2

Upstream product

• 37791-41-6 4-ethylidene-2-phenyl-5-oxazolone 
• 186581-53-3 diazomethane 
• 89363-85-9 (E)-2-phenyl-4-(chloromethylene)-5(4H)-oxazolone 
• 98184-34-0 2-phenyl-5-oxo-4,5-dihydrooxazol-4-idenetriphenylphosphorane 
• 75-36-5 acetyl chloride 
• 495-69-2 Hippuric Acid 

Downstream Products

• 103862-68-6 2-benzoylamino-3-chloro-crotonic acid 
• 105907-17-3 2-benzoylamino-3-chloro-crotonic acid methyl ester 
• 105973-79-3 2-benzoylamino-3-chloro-crotonic acid ethyl ester 
• 5221-67-0 5-methyl-2-phenyloxazole 
• 18735-74-5 5-methyl-2-phenyloxazole-4-carboxylic acid 
• 100063-41-0 methyl 5-methyl-2-phenyloxazole-4-carboxylate 

Relevant academic research and scientific papers

Reactions of 4-phosphoranylidene-5(4H)-oxazolones with acylating agents

Acyl iodides and bromides give in reaction with ylides 1 the expected 4-C- or O-acylation products 2 or 3. In contrast to acyl iodides and bromides, acyl chlorides give in reaction with the ylides 1 Wittig-like reaction products 4(4-(1-chloroalkylidene)-5(4H)-oxazolones), whereas benzoyl fluoride gives 4-(1-benzoyloxybenzylidene)-5(4H)-oxazolones. Some evidence points to a mechanism of the formation of Wittig-like reaction products involving O-acylated ylides as intermediates.

Synthesis and reactions of new 2-substituted 5-phenyl-6-oxa-4-azaspiro[2,4]-hepten-7-one derivatives

Synthesis, reactions and relative configurations of new 2-halogen-, 2-acetyl- and 2-pivaloyl-substituted 5-phenyl-6-oxa-4-azaspiro[2,4]hepten-7-one derivatives 1a-h as potential precursors of 1-aminocyclopropanecarboxylic acids are described.