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d-AMPHETAMINE
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Name

d-AMPHETAMINE

 EINECS 200-112-1
CAS No. 51-64-9 Density 0.946 g/cm3
PSA 26.02000 LogP 3.07860
Solubility Slightly soluble in water. Melting Point 25°C
Formula C9H13 N Boiling Point 201.5 °C at 760 mmHg
Molecular Weight 135.209 Flash Point 87.4 °C
Transport Information N/A Appearance Colorless, oily liquid.
Safety Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Chronic exposure causes central nervous system damage and blood-pressure effects. When heated to decomposition it emits toxic NOx. See other amphetamine entries. Risk Codes 11-23/24/25-39/23/24/25
Molecular Structure Molecular Structure of 51-64-9 (D-AMPHETAMINE HYDROCHLORIDE) Hazard Symbols F,T
Synonyms

Benzeneethanamine,a-methyl-, (S)-;Phenethylamine, a-methyl-, (+)- (8CI);(+)-(S)-Amphetamine;(+)-Phenaminum;(+)-a-Methylphenethylamine;(2S)-(+)-Amphetamine;(S)-(+)-Amphetamine;(S)-(+)-b-Phenylisopropylamine;(S)-1-Methyl-2-phenylethylamine;(S)-1-Phenyl-2-aminopropane;(S)-1-Phenyl-2-propanamine;(S)-1-Phenyl-2-propylamine;(S)-Amphetamine;(S)-a-Methylphenethylamine;D-(+)-Amphetamine;D-Amphetamine;Dexadrine;Dexamfetamine;Dexamphetamine;Dextroamphetamine;Metamina;NSC 73713;d-(S)-Amphetamine;d-Amphetamine;(+)-Amphetamine;

Article Data 169

d-AMPHETAMINE Chemical Properties

The molecular formula of  d-Amphetamine(51-64-9) is C9H13N  and its molecular weight is 135.20. 
Synonyms:(-)-alpha-Phenylpropylamine;(S)-(+)-beta-Phenylisopropylamine;alpha-Methylphenethylamine, d-form;alpha-methylphenethylamine,d-form;amphetamine(d);Amphetamine, (d);Benzeneethanamine, alpha-methyl-, (S)-;component of Amodex
Molecular Structure:

d-AMPHETAMINE History

1、d-amphetamine was first synthesized under the chemical name "phenylisopropylamine" in Berlin, 1887 by the Romanian chemist Lazar Edeleanu. It was not widely marketed until 1932.
Three years later, in 1935, the medical community became aware of the stimulant properties of amphetamine.
2、In 1937 Smith, Kline, and French introduced tablets under the tradename Dexedrine.
3、It quickly became apparent that dextroamphetamine and other amphetamines had a high potential for misuse, although they were not heavily controlled until 1970.
4、Internationally, it has been available under the names AmfeDyn (Italy), Curban (US), Obetrol (Switzerland), Simpamina (Italy), Dexedrine (US), Dextropa (Portugal), and Stild (Spain).

d-AMPHETAMINE Uses

d-Amphetamine(51-64-9) is used as CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake. Controlled substance (stimulant).

d-AMPHETAMINE Toxicity Data With Reference

1.   

scu-rat TDLo:25 mg/kg (female 5-9 D post):REP

   DABBBA    Dissertation Abstracts International, B: The Sciences and Engineering. 31 (1971),6304.
2.   

orl-man TDLo:42 mg/kg/25 W-I

   BIPCBF    Biological Psychiatry. 20 (1985),1332.
3.   

orl-cld TDLo:3600 µg/kg/10 D-I

   AJPSAO    American Journal of Psychiatry. 143 (1985),1176.
4.   

orl-rat LD50:38 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
5.   

ipr-rat LDLo:20 mg/kg

   AEPPAE    Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 195 (1940),647.
6.   

scu-rat LD50:200 mg/kg

   27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,84.
7.   

orl-mus LD50:40 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 41 (1977),329.
8.   

ipr-mus LD50:4400 µg/kg

   AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 161 (1966),206.
9.   

scu-mus LD50:20 mg/kg

   AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 146 (1963),392.
   

 

d-AMPHETAMINE Consensus Reports

d-Amphetamine(51-64-9) is reported in EPA TSCA Inventory.

d-AMPHETAMINE Safety Profile

RIDADR：  3249
HazardClass：  6.1(a)
PackingGroup：  II
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Chronic exposure causes central nervous system damage and blood-pressure effects. When heated to decomposition it emits toxic NOx. See other amphetamine entries.

d-AMPHETAMINE Specification

Contraindications
Do not use in patients with a history of drug abuse. Do not use during or within 14 days following the administration of MAO inhibitors; hypertensive crises may result. Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma and agitated states. Amphetamines should not be used to combat fatigue or to replace rest.