|
1.
1.1
IDENTIFICATION
OF
THE
SUBSTANCE/MIXTURE
AND
OF
THE
COMPANY/UNDERTAKING
Product
identifiers
Product
name
Product
Number
Brand
CAS-No.
:
:
:
:
Chloramphenicol
C0378
56-75-7
1.2
Relevant
identified
uses
of
the
substance
or
mixture
and
uses
advised
against
Identified
uses
:
Laboratory
chemicals,
Manufacture
of
substances 2.
2.1
2.2
HAZARDS
IDENTIFICATION
Classification
of
the
substance
or
mixture
Classification
according
to
Regulation
(EC)
No
1272/2008
[EU-GHS/CLP]
Carcinogenicity
(Category
1B)
Classification
according
to
EU
Directives
67/548/EEC
or
1999/45/EC
May
cause
cancer.
Label
elements
Labelling
according
Regulation
(EC)
No
1272/2008
[CLP]
Pictogram
Signal
word
Hazard
statement(s)
H350
Precautionary
statement(s)
P201
P308
+
P313
Supplemental
Hazard
Statements
Restricted
to
professional
users.
Danger
May
cause
cancer.
Obtain
special
instructions
before
use.
IF
exposed
or
concerned:
Get
medical
advice/
attention.
none
According
to
European
Directive
67/548/EEC
as
amended.
Hazard
symbol(s)
R-phrase(s)
R45
S-phrase(s)
S53
S45
May
cause
cancer.
Avoid
exposure
-
obtain
special
instructions
before
use.
In
case
of
accident
or
if
you
feel
unwell,
seek
medical
advice
immediately
(show
the
label
where
possible).
Restricted
to
professional
users.
2.3
3.
3.1
Other
hazards
-
none
COMPOSITION/INFORMATION
ON
INGREDIENTS
Substances
Synonyms
Formula
Molecular
Weight
Component
Chloramphenicol
:
:
:
D-(
?
)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
Chloromycetin
D-(
?
)-threo-2,2-Dichloro-N-
[β
-hydroxy-
α
-(hydroxymethyl)-
β
-(4-
nitrophenyl)ethyl]acetamide
D-threo-2,2-Dichloro-N-
[β
-hydroxy-
α
-(hydroxymethyl)-4-
nitrophenethyl]acetamide
C11H12Cl2N2O5
323,13
g/mol
Concentration
CAS-No.
EC-No.
56-75-7
200-287-4
-
4.
4.1
4.2
4.3
5.
5.1
FIRST
AID
MEASURES
Description
of
first
aid
measures
General
advice
Consult
a
physician.
Show
this
safety
data
sheet
to
the
doctor
in
attendance.
If
inhaled
If
breathed
in,
move
person
into
fresh
air.
If
not
breathing,
give
artificial
respiration.
Consult
a
physician.
In
case
of
skin
contact
Wash
off
with
soap
and
plenty
of
water.
Consult
a
physician.
In
case
of
eye
contact
Flush
eyes
with
water
as
a
precaution.
If
swallowed
Never
give
anything
by
mouth
to
an
unconscious
person.
Rinse
mouth
with
water.
Consult
a
physician.
Most
important
symptoms
and
effects,
both
acute
and
delayed
Nausea,
Headache,
Vomiting
Indication
of
any
immediate
medical
attention
and
special
treatment
needed
no
data
available
FIREFIGHTING
MEASURES
Extinguishing
media
Suitable
extinguishing
media
Use
water
spray,
alcohol-resistant
foam,
dry
chemical
or
carbon
dioxide.
5.2
5.3
5.4
6.
6.1
6.2
6.3
6.4
7.
7.1
7.2
7.3
8.
8.1
8.2
Special
hazards
arising
from
the
substance
or
mixture
Carbon
oxides,
nitrogen
oxides
(NOx),
Hydrogen
chloride
gas
Carbon
oxides,
nitrogen
oxides
(NOx),
Hydrogen
chloride
gas
Advice
for
firefighters
Wear
self
contained
breathing
apparatus
for
fire
fighting
if
necessary.
Further
information
no
data
available
ACCIDENTAL
RELEASE
MEASURES
Personal
precautions,
protective
equipment
and
emergency
procedures
Use
personal
protective
equipment.
Avoid
dust
formation.
Avoid
breathing
vapors,
mist
or
gas.
Ensure
adequate
ventilation.
Evacuate
personnel
to
safe
areas.
Avoid
breathing
dust.
Environmental
precautions
Prevent
further
leakage
or
spillage
if
safe
to
do
so.
Do
not
let
product
enter
drains.
Methods
and
materials
for
containment
and
cleaning
up
Pick
up
and
arrange
disposal
without
creating
dust.
Sweep
up
and
shovel.
Keep
in
suitable,
closed
containers
for
disposal.
Reference
to
other
sections
For
disposal
see
section
13.
HANDLING
AND
STORAGE
Precautions
for
safe
handling
Avoid
formation
of
dust
and
aerosols.Avoid
exposure
-
obtain
special
instructions
before
use.
Provide
appropriate
exhaust
ventilation
at
places
where
dust
is
formed.Normal
measures
for
preventive
fire
protection.
Conditions
for
safe
storage,
including
any
incompatibilities
Store
in
cool
place.
Keep
container
tightly
closed
in
a
dry
and
well-ventilated
place.
Specific
end
uses
no
data
available
EXPOSURE
CONTROLS/PERSONAL
PROTECTION
Control
parameters
Components
with
workplace
control
parameters
Exposure
controls
Appropriate
engineering
controls
Handle
in
accordance
with
good
industrial
hygiene
and
safety
practice.
Wash
hands
before
breaks
and
at
the
end
of
workday.
Personal
protective
equipment
Eye/face
protection
Safety
glasses
with
side-shields
conforming
to
EN166
Use
equipment
for
eye
protection
tested
and
approved
under
appropriate
government
standards
such
as
NIOSH
(US)
or
EN
166(EU).
Skin
protection
Handle
with
gloves.
Gloves
must
be
inspected
prior
to
use.
Use
proper
glove
removal
technique
(without
touching
glove's
outer
surface)
to
avoid
skin
contact
with
this
product.
Dispose
of
contaminated
gloves
after
use
in
accordance
with
applicable
laws
and
good
laboratory
practices.
Wash
and
dry
hands.
The
selected
protective
gloves
have
to
satisfy
the
specifications
of
EU
Directive
89/686/EEC
and
the
standard
EN
374
derived
from
it.
Immersion
protection
Material:
Nitrile
rubber
Minimum
layer
thickness:
0,11
mm
Break
through
time:
>
480
min
Material
tested:Dermatril?
(
Z677272,
Size
M)
Splash
protection
Material:
Nitrile
rubber
Minimum
layer
thickness:
0,11
mm
Break
through
time:
>
30
min
Material
tested:Dermatril?
(
Z677272,
Size
M)
data
source:
KCL
GmbH,
D-36124
Eichenzell,
phone
+49
(0)6659
873000,
e-mail
sales@kcl.de,
test
method:
EN374
If
used
in
solution,
or
mixed
with
other
substances,
and
under
conditions
which
differ
from
EN
374,
contact
the
supplier
of
the
CE
approved
gloves.
This
recommendation
is
advisory
only
and
must
be
evaluated
by
an
Industrial
Hygienist
familiar
with
the
specific
situation
of
anticipated
use
by
our
customers.
It
should
not
be
construed
as
offering
an
approval
for
any
specific
use
scenario.
Body
Protection
impervious
clothing,
The
type
of
protective
equipment
must
be
selected
according
to
the
concentration
and
amount
of
the
dangerous
substance
at
the
specific
workplace.
Respiratory
protection
Where
risk
assessment
shows
air-purifying
respirators
are
appropriate
use
a
full-face
particle
respirator
type
N100
(US)
or
type
P3
(EN
143)
respirator
cartridges
as
a
backup
to
engineering
controls.
If
the
respirator
is
the
sole
means
of
protection,
use
a
full-face
supplied
air
respirator.
Use
respirators
and
components
tested
and
approved
under
appropriate
government
standards
such
as
NIOSH
(US)
or
CEN
(EU).
9.
9.1
PHYSICAL
AND
CHEMICAL
PROPERTIES
Information
on
basic
physical
and
chemical
properties
a)
b)
c)
d)
e)
f)
g)
h)
Appearance
Odour
Odour
Threshold
pH
Melting
point/freezing
point
Initial
boiling
point
and
boiling
range
Flash
point
Evaporation
rate
Form:
crystalline
Colour:
light
yellow
no
data
available
no
data
available
no
data
available
149
°C
no
data
available
no
data
available
no
data
available
i)
Flammability
(solid,
gas)
no
data
available
j)
k)
l)
Upper/lower
flammability
or
explosive
limits
Vapour
pressure
Vapour
density
no
data
available
no
data
available
no
data
available
m)
Relative
density
no
data
available
n)
o)
p)
q)
Water
solubility
Partition
coefficient:
n-
octanol/water
Autoignition
temperature
Decomposition
temperature
practically
insoluble
no
data
available
no
data
available
no
data
available
r)
s)
t)
Viscosity
Explosive
properties
Oxidizing
properties
no
data
available
no
data
available
no
data
available
9.2
Other
safety
information
Solubility
in
other
solvents
Ethanol
10.
10.1
10.2
10.3
10.4
10.5
10.6
11.
11.1
STABILITY
AND
REACTIVITY
Reactivity
no
data
available
Chemical
stability
no
data
available
Possibility
of
hazardous
reactions
no
data
available
Conditions
to
avoid
no
data
available
Incompatible
materials
acids,
Acid
chlorides,
Acid
anhydrides,
Oxidizing
agents
Hazardous
decomposition
products
Other
decomposition
products
-
no
data
available
TOXICOLOGICAL
INFORMATION
Information
on
toxicological
effects
Acute
toxicity
LD50
Oral
-
rat
-
2.500
mg/kg
Skin
corrosion/irritation
no
data
available
Serious
eye
damage/eye
irritation
no
data
available
Respiratory
or
skin
sensitization
Prolonged
or
repeated
exposure
may
cause
allergic
reactions
in
certain
sensitive
individuals.
Germ
cell
mutagenicity
Laboratory
experiments
have
shown
mutagenic
effects.
Genotoxicity
in
vitro
-
rat
-
Liver
DNA
damage
Genotoxicity
in
vivo
-
mouse
-
Intraperitoneal
Cytogenetic
analysis
Carcinogenicity
This
product
is
or
contains
a
component
that
has
been
reported
to
be
probably
carcinogenic
based
on
its
IARC,
OSHA,
ACGIH,
NTP,
or
EPA
classification.
Possible
human
carcinogen
IARC:
2A
-
Group
2A:
Probably
carcinogenic
to
humans
(Chloramphenicol)
Reproductive
toxicity
no
data
available
Specific
target
organ
toxicity
-
single
exposure
no
data
available
Specific
target
organ
toxicity
-
repeated
exposure
no
data
available
Aspiration
hazard
no
data
available
Potential
health
effects
Inhalation
Ingestion
Skin
Eyes
May
be
harmful
if
inhaled.
May
cause
respiratory
tract
irritation.
May
be
harmful
if
swallowed.
May
be
harmful
if
absorbed
through
skin.
May
cause
skin
irritation.
May
cause
eye
irritation.
Signs
and
Symptoms
of
Exposure
Nausea,
Headache,
Vomiting
Additional
Information
RTECS:
AB6825000
12.
12.1
ECOLOGICAL
INFORMATION
Toxicity
Toxicity
to
daphnia
and
other
aquatic
invertebrates
EC50
-
Daphnia
magna
(Water
flea)
-
345
mg/l
-
48
h
12.2
12.3
12.4
12.5
12.6
13.
13.1
14.
14.1
Persistence
and
degradability
no
data
available
Bioaccumulative
potential
no
data
available
Mobility
in
soil
no
data
available
Results
of
PBT
and
vPvB
assessment
no
data
available
Other
adverse
effects
no
data
available
DISPOSAL
CONSIDERATIONS
Waste
treatment
methods
Product
Offer
surplus
and
non-recyclable
solutions
to
a
licensed
disposal
company.
Contact
a
licensed
professional
waste
disposal
service
to
dispose
of
this
material.
Dissolve
or
mix
the
material
with
a
combustible
solvent
and
burn
in
a
chemical
incinerator
equipped
with
an
afterburner
and
scrubber.
Contaminated
packaging
Dispose
of
as
unused
product.
TRANSPORT
INFORMATION
UN
number
ADR/RID:
-
14.2
UN
proper
shipping
name
ADR/RID:
Not
dangerous
goods
IMDG:
Not
dangerous
goods
IATA:
Not
dangerous
goods
14.3
Transport
hazard
class(es)
ADR/RID:
-
14.4
Packaging
group
ADR/RID:
-
IMDG:
-
IMDG:
-
IMDG:
-
IATA:
-
IATA:
-
IATA:
-
14.5
Environmental
hazards
14.6
15.
ADR/RID:
no
Special
precautions
for
user
no
data
available
REGULATORY
INFORMATION
IMDG
Marine
pollutant:
no
IATA:
no
This
safety
datasheet
complies
with
the
requirements
of
Regulation
(EC)
No.
1907/2006.
15.1
15.2
16.
Safety,
health
and
environmental
regulations/legislation
specific
for
the
substance
or
mixture
no
data
available
Chemical
Safety
Assessment
no
data
available
OTHER
INFORMATION
Further
information
The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.
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Chloramphenicol
China (Mainland)] 
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United States] 
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